NEB

Protein identityUniProt · HPA

UniProt accession

P20929

Gene

NEB

Ensembl

ENSG00000183091

Chromosome

2

Canonical length

8525 aa

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

Quaternary structure

Homooligomer

OverviewNCBI Gene

This gene encodes nebulin, a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. In most vertebrates, nebulin accounts for 3 to 4% of the total myofibrillar protein. The encoded protein contains approximately 30-amino acid long modules that can be classified into 7 types and other repeated modules. Protein isoform sizes vary from 600 to 800 kD due to alternative splicing that is tissue-, species-,and developmental stage-specific. Of the 183 exons in the nebulin gene, at least 43 are alternatively spliced, although exons 143 and 144 are not found in the same transcript. Of the several thousand transcript variants predicted for nebulin, the RefSeq Project has decided to create three representative RefSeq records. Mutations in this gene are associated with recessive nemaline myopathy. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

8525 residues, UniProt reviewed canonical sequence.

>P20929|NEB
     1  MADDEDYEEV VEYYTEEVVY EEVPGETITK IYETTTTRTS DYEQSETSKP ALAQPALAQP
    61  ASAKPVERRK VIRKKVDPSK FMTPYIAHSQ KMQDLFSPNK YKEKFEKTKG QPYASTTDTP
   121  ELRRIKKVQD QLSEVKYRMD GDVAKTICHV DEKAKDIEHA KKVSQQVSKV LYKQNWEDTK
   181  DKYLLPPDAP ELVQAVKNTA MFSKKLYTED WEADKSLFYP YNDSPELRRV AQAQKALSDV
   241  AYKKGLAEQQ AQFTPLADPP DIEFAKKVTN QVSKQKYKED YENKIKGKWS ETPCFEVANA
   301  RMNADNISTR KYQEDFENMK DQIYFMQTET PEYKMNKKAG VAASKVKYKE DYEKNKGKAD
   361  YNVLPASENP QLRQLKAAGD ALSDKLYKEN YEKTKAKSIN YCETPKFKLD TVLQNFSSDK
   421  KYKDSYLKDI LGHYVGSFED PYHSHCMKVT AQNSDKNYKA EYEEDRGKGF FPQTITQEYE
   481  AIKKLDQCKD HTYKVHPDKT KFTQVTDSPV LLQAQVNSKQ LSDLNYKAKH ESEKFKCHIP
   541  PDTPAFIQHK VNAYNLSDNL YKQDWEKSKA KKFDIKVDAI PLLAAKANTK NTSDVMYKKD
   601  YEKNKGKMIG VLSINDDPKM LHSLKVAKNQ SDRLYKENYE KTKAKSMNYC ETPKYQLDTQ
   661  LKNFSEARYK DLYVKDVLGH YVGSMEDPYH THCMKVAAQN SDKSYKAEYE EDKGKCYFPQ
   721  TITQEYEAIK KLDQCKDHTY KVHPDKTKFT AVTDSPVLLQ AQLNTKQLSD LNYKAKHEGE
   781  KFKCHIPADA PQFIQHRVNA YNLSDNVYKQ DWEKSKAKKF DIKVDAIPLL AAKANTKNTS
   841  DVMYKKDYEK SKGKMIGALS INDDPKMLHS LKTAKNQSDR EYRKDYEKSK TIYTAPLDML
   901  QVTQAKKSQA IASDVDYKHI LHSYSYPPDS INVDLAKKAY ALQSDVEYKA DYNSWMKGCG
   961  WVPFGSLEME KAKRASDILN EKKYRQHPDT LKFTSIEDAP ITVQSKINQA QRSDIAYKAK
  1021  GEEIIHKYNL PPDLPQFIQA KVNAYNISEN MYKADLKDLS KKGYDLRTDA IPIRAAKAAR
  1081  QAASDVQYKK DYEKAKGKMV GFQSLQDDPK LVHYMNVAKI QSDREYKKDY EKTKSKYNTP
  1141  HDMFNVVAAK KAQDVVSNVN YKHSLHHYTY LPDAMDLELS KNMMQIQSDN VYKEDYNNWM
  1201  KGIGWIPIGS LDVEKVKKAG DALNEKKYRQ HPDTLKFTSI VDSPVMVQAK QNTKQVSDIL
  1261  YKAKGEDVKH KYTMSPDLPQ FLQAKCNAYN ISDVCYKRDW YDLIAKGNNV LGDAIPITAA
  1321  KASRNIASDY KYKEAYEKSK GKHVGFRSLQ DDPKLVHYMN VAKLQSDREY KKNYENTKTS
  1381  YHTPGDMVSI TAAKMAQDVA TNVNYKQPLH HYTYLPDAMS LEHTRNVNQI QSDNVYKDEY
  1441  NSFLKGIGWI PIGSLEVEKV KKAGDALNER KYRQHPDTVK FTSVPDSMGM VLAQHNTKQL
  1501  SDLNYKVEGE KLKHKYTIDP ELPQFIQAKV NALNMSDAHY KADWKKTIAK GYDLRPDAIP
  1561  IVAAKSSRNI ASDCKYKEAY EKAKGKQVGF LSLQDDPKLV HYMNVAKIQS DREYKKGYEA
  1621  SKTKYHTPLD MVSVTAAKKS QEVATNANYR QSYHHYTLLP DALNVEHSRN AMQIQSDNLY
  1681  KSDFTNWMKG IGWVPIESLE VEKAKKAGEI LSEKKYRQHP EKLKFTYAMD TMEQALNKSN
  1741  KLNMDKRLYT EKWNKDKTTI HVMPDTPDIL LSRVNQITMS DKLYKAGWEE EKKKGYDLRP
  1801  DAIAIKAARA SRDIASDYKY KKAYEQAKGK HIGFRSLEDD PKLVHFMQVA KMQSDREYKK
  1861  GYEKSKTSFH TPVDMLSVVA AKKSQEVATN ANYRNVIHTY NMLPDAMSFE LAKNMMQIQS
  1921  DNQYKADYAD FMKGIGWLPL GSLEAEKNKK AMEIISEKKY RQHPDTLKYS TLMDSMNMVL
  1981  AQNNAKIMNE HLYKQAWEAD KTKVHIMPDI PQIILAKANA INMSDKLYKL SLEESKKKGY
  2041  DLRPDAIPIK AAKASRDIAS DYKYKYNYEK GKGKMVGFRS LEDDPKLVHS MQVAKMQSDR
  2101  EYKKNYENTK TSYHTPADML SVTAAKDAQA NITNTNYKHL IHKYILLPDA MNIELTRNMN
  2161  RIQSDNEYKQ DYNEWYKGLG WSPAGSLEVE KAKKATEYAS DQKYRQHPSN FQFKKLTDSM
  2221  DMVLAKQNAH TMNKHLYTID WNKDKTKIHV MPDTPDILQA KQNQTLYSQK LYKLGWEEAL
  2281  KKGYDLPVDA ISVQLAKASR DIASDYKYKQ GYRKQLGHHV GFRSLQDDPK LVLSMNVAKM
  2341  QSEREYKKDF EKWKTKFSSP VDMLGVVLAK KCQELVSDVD YKNYLHQWTC LPDQNDVVQA
  2401  KKVYELQSEN LYKSDLEWLR GIGWSPLGSL EAEKNKRASE IISEKKYRQP PDRNKFTSIP
  2461  DAMDIVLAKT NAKNRSDRLY REAWDKDKTQ IHIMPDTPDI VLAKANLINT SDKLYRMGYE
  2521  ELKRKGYDLP VDAIPIKAAK ASREIASEYK YKEGFRKQLG HHIGARNIED DPKMMWSMHV
  2581  AKIQSDREYK KDFEKWKTKF SSPVDMLGVV LAKKCQTLVS DVDYKNYLHQ WTCLPDQSDV
  2641  IHARQAYDLQ SDNLYKSDLQ WLKGIGWMTS GSLEDEKNKR ATQILSDHVY RQHPDQFKFS
  2701  SLMDSIPMVL AKNNAITMNH RLYTEAWDKD KTTVHIMPDT PEVLLAKQNK VNYSEKLYKL
  2761  GLEEAKRKGY DMRVDAIPIK AAKASRDIAS EFKYKEGYRK QLGHHIGARA IRDDPKMMWS
  2821  MHVAKIQSDR EYKKDFEKWK TKFSSPVDML GVVLAKKCQT LVSDVDYKNY LHQWTCLPDQ
  2881  SDVIHARQAY DLQSDNMYKS DLQWMRGIGW VSIGSLDVEK CKRATEILSD KIYRQPPDRF
  2941  KFTSVTDSLE QVLAKNNAIT MNKRLYTEAW DKDKTQIHIM PDTPEIMLAR MNKINYSESL
  3001  YKLANEEAKK KGYDLRSDAI PIVAAKASRD IISDYKYKDG YCKQLGHHIG ARNIEDDPKM
  3061  MWSMHVAKIQ SDREYKKDFE KWKTKFSSPV DMLGVVLAKK CQTLVSDVDY KNYLHEWTCL
  3121  PDQSDVIHAR QAYDLQSDNI YKSDLQWLRG IGWVPIGSMD VVKCKRATEI LSDNIYRQPP
  3181  DKLKFTSVTD SLEQVLAKNN ALNMNKRLYT EAWDKDKTQI HIMPDTPEIM LARQNKINYS
  3241  ETLYKLANEE AKKKGYDLRS DAIPIVAAKA SRDVISDYKY KDGYRKQLGH HIGARNIEDD
  3301  PKMMWSMHVA KIQSDREYKK DFEKWKTKFS SPVDMLGVVL AKKCQTLVSD VDYKNYLHEW
  3361  TCLPDQNDVI HARQAYDLQS DNIYKSDLQW LRGIGWVPIG SMDVVKCKRA AEILSDNIYR
  3421  QPPDKLKFTS VTDSLEQVLA KNNALNMNKR LYTEAWDKDK TQVHIMPDTP EIMLARQNKI
  3481  NYSESLYRQA MEEAKKEGYD LRSDAIPIVA AKASRDIASD YKYKEAYRKQ LGHHIGARAV
  3541  HDDPKIMWSL HIAKVQSDRE YKKDFEKYKT RYSSPVDMLG IVLAKKCQTL VSDVDYKHPL
  3601  HEWICLPDQN DIIHARKAYD LQSDNLYKSD LEWMKGIGWV PIDSLEVVRA KRAGELLSDT
  3661  IYRQRPETLK FTSITDTPEQ VLAKNNALNM NKRLYTEAWD NDKKTIHVMP DTPEIMLAKL
  3721  NRINYSDKLY KLALEESKKE GYDLRLDAIP IQAAKASRDI ASDYKYKEGY RKQLGHHIGA
  3781  RNIKDDPKMM WSIHVAKIQS DREYKKEFEK WKTKFSSPVD MLGVVLAKKC QILVSDIDYK
  3841  HPLHEWTCLP DQNDVIQARK AYDLQSDAIY KSDLEWLRGI GWVPIGSVEV EKVKRAGEIL
  3901  SDRKYRQPAD QLKFTCITDT PEIVLAKNNA LTMSKHLYTE AWDADKTSIH VMPDTPDILL
  3961  AKSNSANISQ KLYTKGWDES KMKDYDLRAD AISIKSAKAS RDIASDYKYK EAYEKQKGHH
  4021  IGAQSIEDDP KIMCAIHAGK IQSEREYKKE FQKWKTKFSS PVDMLSILLA KKCQTLVTDI
  4081  DYRNYLHEWT CMPDQNDIIQ AKKAYDLQSD SVYKADLEWL RGIGWMPEGS VEMNRVKVAQ
  4141  DLVNERLYRT RPEALSFTSI VDTPEVVLAK ANSLQISEKL YQEAWNKDKS NITIPSDTPE
  4201  MLQAHINALQ ISNKLYQKDW NDAKQKGYDI RADAIEIKHA KASREIASEY KYKEGYRKQL
  4261  GHHMGFRTLQ DDPKSVWAIH AAKIQSDREY KKAYEKSKGI HNTPLDMMSI VQAKKCQVLV
  4321  SDIDYRNYLH QWTCLPDQND VIQAKKAYDL QSDNLYKSDL EWLKGIGWLP EGSVEVMRVK
  4381  NAQNLLNERL YRIKPEALKF TSIVDTPEVI QAKINAVQIS EPLYRDAWEK EKANVNVPAD
  4441  TPLMLQSKIN ALQISNKRYQ QAWEDVKMTG YDLRADAIGI QHAKASRDIA SDYLYKTAYE
  4501  KQKGHYIGCR SAKEDPKLVW AANVLKMQND RLYKKAYNDH KAKISIPVDM VSISAAKEGQ
  4561  ALASDVDYRH YLHHWSCFPD QNDVIQARKA YDLQSDSVYK ADLEWLRGIG WMPEGSVEMN
  4621  RVKVAQDLVN ERLYRTRPEA LSFTSIVDTP EVVLAKANSL QISEKLYQEA WNKDKSNITI
  4681  PSDTPEMLQA HINALQISNK LYQKDWNDTK QKGYDIRADA IEIKHAKASR EIASEYKYKE
  4741  GYRKQLGHHM GFRTLQDDPK SVWAIHAAKI QSDREYKKAY EKSKGIHNTP LDMMSIVQAK
  4801  KCQVLVSDID YRNYLHQWTC LPDQNDVIQA KKAYDLQSDN LYKSDLEWLK GIGWLPEGSV
  4861  EVMRVKNAQN LLNERLYRIK PEALKFTSIV DTPEVIQAKI NAVQISEPLY RNAWEKEKAN
  4921  VNVPADTPLM LQSKINALQI SNKRYQQAWE DVKMTGYDLR ADAIGIQHAK ASRDIASDYL
  4981  YKTAYEKQKG HYIGCRSAKE DPKLVWAANV LKMQNDRLYK KAYNDHKAKI SIPVDMVSIS
  5041  AAKEGQALAS DVDYRHYLHH WSCFPDQNDV IQARKAYDLQ SDSVYKADLE WLRGIGWMPE
  5101  GSVEMNRVKV AQDLVNERLY RTRPEALSFT SIVDTPEVVL AKANSLQISE KLYQEAWNKD
  5161  KSNITIPSDT PEMLQAHINA LQISNKLYQK DWNDTKQKGY DIRADAIEIK HAKASREIAS
  5221  EYKYKEGYRK QLGHHMGFRT LQDDPKSVWA IHAAKIQSDR EYKKAYEKSK GIHNTPLDMM
  5281  SIVQAKKCQV LVSDIDYRNY LHQWTCLPDQ NDVIQAKKAY DLQSDNLYKS DLEWLKGIGW
  5341  LPEGSVEVMR VKNAQNLLNE RLYRIKPEAL KFTSIVDTPE VIQAKINAVQ ISEPLYRDAW
  5401  EKEKANVNVP ADTPLMLQSK INALQISNKR YQQAWEDVKM TGYDLRADAI GIQHAKASRD
  5461  IASDYLYKTA YEKQKGHYIG CRSAKEDPKL VWAANVLKMQ NDRLYKKAYN DHKAKISIPV
  5521  DMVSISAAKE GQALASDVDY RHYLHRWSCF PDQNDVIQAR KAYDLQSDAL YKADLEWLRG
  5581  IGWMPQGSPE VLRVKNAQNI FCDSVYRTPV VNLKYTSIVD TPEVVLAKSN AENISIPKYR
  5641  EVWDKDKTSI HIMPDTPEIN LARANALNVS NKLYREGWDE MKAGCDVRLD AIPIQAAKAS
  5701  REIASDYKYK LDHEKQKGHY VGTLTARDDN KIRWALIADK LQNEREYRLD WAKWKAKIQS
  5761  PVDMLSILHS KNSQALVSDM DYRNYLHQWT CMPDQNDVIQ AKKAYELQSD NVYKADLEWL
  5821  RGIGWMPNDS VSVNHAKHAA DIFSEKKYRT KIETLNFTPV DDRVDYVTAK QSGEILDDIK
  5881  YRKDWNATKS KYTLTETPLL HTAQEAARIL DQYLYKEGWE RQKATGYILP PDAVPFVHAH
  5941  HCNDVQSELK YKAEHVKQKG HYVGVPTMRD DPKLVWFEHA GQIQNERLYK EDYHKTKAKI
  6001  NIPADMVSVL AAKQGQTLVS DIDYRNYLHQ WMCHPDQNDV IQARKAYDLQ SDNVYRADLE
  6061  WLRGIGWIPL DSVDHVRVTK NQEMMSQIKY KKNALENYPN FRSVVDPPEI VLAKINSVNQ
  6121  SDVKYKETFN KAKGKYTFSP DTPHISHSKD MGKLYSTILY KGAWEGTKAY GYTLDERYIP
  6181  IVGAKHADLV NSELKYKETY EKQKGHYLAG KVIGEFPGVV HCLDFQKMRS ALNYRKHYED
  6241  TKANVHIPND MMNHVLAKRC QYILSDLEYR HYFHQWTSLL EEPNVIRVRN AQEILSDNVY
  6301  KDDLNWLKGI GCYVWDTPQI LHAKKSYDLQ SQLQYTAAGK ENLQNYNLVT DTPLYVTAVQ
  6361  SGINASEVKY KENYHQIKDK YTTVLETVDY DRTRNLKNLY SSNLYKEAWD RVKATSYILP
  6421  SSTLSLTHAK NQKHLASHIK YREEYEKFKA LYTLPRSVDD DPNTARCLRV GKLNIDRLYR
  6481  SVYEKNKMKI HIVPDMVEMV TAKDSQKKVS EIDYRLRLHE WICHPDLQVN DHVRKVTDQI
  6541  SDIVYKDDLN WLKGIGCYVW DTPEILHAKH AYDLRDDIKY KAHMLKTRND YKLVTDTPVY
  6601  VQAVKSGKQL SDAVYHYDYV HSVRGKVAPT TKTVDLDRAL HAYKLQSSNL YKTSLRTLPT
  6661  GYRLPGDTPH FKHIKDTRYM SSYFKYKEAY EHTKAYGYTL GPKDVPFVHV RRVNNVTSER
  6721  LYRELYHKLK DKIHTTPDTP EIRQVKKTQE AVSELIYKSD FFKMQGHMIS LPYTPQVIHC
  6781  RYVGDITSDI KYKEDLQVLK GFGCFLYDTP DMVRSRHLRK LWSNYLYTDK ARKMRDKYKV
  6841  VLDTPEYRKV QELKTHLSEL VYRAAGKKQK SIFTSVPDTP DLLRAKRGQK LQSQYLYVEL
  6901  ATKERPHHHA GNQTTALKHA KDVKDMVSEK KYKIQYEKMK DKYTPVPDTP ILIRAKRAYW
  6961  NASDLRYKET FQKTKGKYHT VKDALDIVYH RKVTDDISKI KYKENYMSQL GIWRSIPDRP
  7021  EHFHHRAVTD TVSDVKYKED LTWLKGIGCY AYDTPDFTLA EKNKTLYSKY KYKEVFERTK
  7081  SDFKYVADSP INRHFKYATQ LMNERKYKSS AKMFLQHGCN EILRPDMLTA LYNSHMWSQI
  7141  KYRKNYEKSK DKFTSIVDTP EHLRTTKVNK QISDILYKLE YNKAKPRGYT TIHDTPMLLH
  7201  VRKVKDEVSD LKYKEVYQRN KSNCTIEPDA VHIKAAKDAY KVNTNLDYKK QYEANKAHWK
  7261  WTPDRPDFLQ AAKSSLQQSD FEYKLDREFL KGCKLSVTDD KNTVLALRNT LIESDLKYKE
  7321  KHVKERGTCH AVPDTPQILL AKTVSNLVSE NKYKDHVKKH LAQGSYTTLP ETRDTVHVKE
  7381  VTKHVSDTNY KKKFVKEKGK SNYSIMLEPP EVKHAMEVAK KQSDVAYRKD AKENLHYTTV
  7441  ADRPDIKKAT QAAKQASEVE YRAKHRKEGS HGLSMLGRPD IEMAKKAAKL SSQVKYRENF
  7501  DKEKGKTPKY NPKDSQLYKV MKDANNLASE VKYKADLKKL HKPVTDMKES LIMNHVLNTS
  7561  QLASSYQYKK KYEKSKGHYH TIPDNLEQLH LKEATELQSI VKYKEKYEKE RGKPMLDFET
  7621  PTYITAKESQ QMQSGKEYRK DYEESIKGRN LTGLEVTPAL LHVKYATKIA SEKEYRKDLE
  7681  ESIRGKGLTE MEDTPDMLRA KNATQILNEK EYKRDLELEV KGRGLNAMAN ETPDFMRARN
  7741  ATDIASQIKY KQSAEMEKAN FTSVVDTPEI IHAQQVKNLS SQKKYKEDAE KSMSYYETVL
  7801  DTPEIQRVRE NQKNFSLLQY QCDLKNSKGK ITVVQDTPEI LRVKENQKNF SSVLYKEDVS
  7861  PGTAIGKTPE MMRVKQTQDH ISSVKYKEAI GQGTPIPDLP EVKRVKETQK HISSVMYKEN
  7921  LGTGIPTTVT PEIERVKRNQ ENFSSVLYKE NLGKGIPTPI TPEMERVKRN QENFSSILYK
  7981  ENLSKGTPLP VTPEMERVKL NQENFSSVLY KENVGKGIPI PITPEMERVK HNQENFSSVL
  8041  YKENLGTGIP IPITPEMQRV KHNQENLSSV LYKENMGKGT PLPVTPEMER VKHNQENISS
  8101  VLYKENMGKG TPLPVTPEME RVKHNQENIS SVLYKENMGK GTPLAVTPEM ERVKHNQENI
  8161  SSVLYKENVG KATATPVTPE MQRVKRNQEN ISSVLYKENL GKATPTPFTP EMERVKRNQE
  8221  NFSSVLYKEN MRKATPTPVT PEMERAKRNQ ENISSVLYSD SFRKQIQGKA AYVLDTPEMR
  8281  RVRETQRHIS TVKYHEDFEK HKGCFTPVVT DPITERVKKN MQDFSDINYR GIQRKVVEME
  8341  QKRNDQDQET ITGLRVWRTN PGSVFDYDPA EDNIQSRSLH MINVQAQRRS REQSRSASAL
  8401  SISGGEEKSE HSEAPDHHLS TYSDGGVFAV STAYKHAKTT ELPQQRSSSV ATQQTTVSSI
  8461  PSHPSTAGKI FRAMYDYMAA DADEVSFKDG DAIINVQAID EGWMYGTVQR TGRTGMLPAN
  8521  YVEAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0

Highest tissue expression

7,182 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NEB.

Disease | AllUniProt

Conditions NEB is implicated in, by any mechanism.

• Nemaline myopathy 2 (NEM2) MIM:256030
• Arthrogryposis multiplex congenita 6 (AMC6) MIM:619334

Disease | GeneticClinVar

1,884 pathogenic / likely-pathogenic of 12,522 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Nemaline myopathy 2
• Arthrogryposis multiplex congenita 6
• Nemaline myopathy
• NEB-related disorder
• Inborn genetic diseases

Disease | ImmuneIEDB

Conditions an epitope on NEB was assayed in.

• skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.42

gnomAD pLI

0

gnomAD missense Z

-0.04

DepMap mean gene effect

0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cardiac muscle thin filament assembly
• muscle organ development
• regulation of actin filament length
• somatic muscle development

Molecular functions

• actin filament binding
• structural constituent of muscle

Cellular components

• actin cytoskeleton
• cytosol
• extracellular exosome
• Z disc

Protein domainsUniProt · Pfam · InterPro

• Nebulin repeat
• SH3 domain
• Nebulin-like
• SH3-like domain superfamily
• Nebulin/Nebulette
• Nebulin repeat
• Variant SH3 domain
• Nebulin, SH3 domain

KeywordsUniProt

• Actin-binding
• Cytoplasm
• Cytoskeleton
• Muscle protein
• Nemaline myopathy
• Repeat
• SH3 domain

InteractionsUniProt · HPA

Protein binding partners of NEB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SVIL
• DES
• MYPN
• TTN
• KLHL41
• XIRP2