NDUFC2-KCTD14
NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2
Also known as: NDUCR_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- E9PQ53
- Gene
- NDUFC2-KCTD14
- Ensembl
- ENSG00000259112
- Chromosome
- 11
- Canonical length
- 114 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
This locus represents naturally occurring read-through transcription between the neighboring NDUFC2 (NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa) and KCTD14 (potassium channel tetramerisation domain containing 14) genes on chromosome 11. The read-through transcripts share sequence identity with the upstream gene product and one variant has a frameshifted C-terminal region derived from the downstream gene exons. [provided by RefSeq, Feb 2011]
Canonical amino-acid sequenceUniProt
114 residues, UniProt reviewed canonical sequence.
>E9PQ53|NDUFC2-KCTD14
1 MIARRNPEPL RFLPDEARSL PPPKLTDPRL LYIGFLGYCS GLIDNLIRRR PIATAGLHRQ
61 LLYITAFFFA GYYLVKREDY LYAVRDREMF GYMKLHPEDF PEEDVYCCGA ERRGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NDUFC2-KCTD14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 16 nTPM
Expression across tissuesHPA
Tissue
- tongue: 16 nTPM
- duodenum: 12 nTPM
- seminal vesicle: 11 nTPM
- salivary gland: 11 nTPM
- skeletal muscle: 10 nTPM
- bone marrow: 10 nTPM
Single-cell type
- adipocytes: 180 nCPM
- adrenal medulla cells: 11 nCPM
- retinal ganglion cells: 7.7 nCPM
- epicardial cells: 6.8 nCPM
- brain excitatory neurons: 5.3 nCPM
- brain inhibitory neurons: 4.3 nCPM
Immune cell
- plasmacytoid DC: 214 nTPM
- total PBMC: 194 nTPM
- T-reg: 136 nTPM
- myeloid DC: 131 nTPM
- memory B-cell: 120 nTPM
- basophil: 114 nTPM
Brain region
- cerebral cortex: 9.8 nTPM
- cerebellum: 9.5 nTPM
- hippocampal formation: 8.9 nTPM
- basal ganglia: 8.6 nTPM
- hypothalamus: 8.5 nTPM
- white matter: 8.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.86
- gnomAD pLI
- 0.66
- gnomAD missense Z
- 0.39
OntologyGO
Biological processes
- NADH to ubiquinone
- mitochondrial electron transport
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NDUFC2-KCTD14 as an antibody target. Whether an autoantibody or antibody against NDUFC2-KCTD14 could matter depends on whether native NDUFC2-KCTD14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NDUFC2-KCTD14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NDUFC2-KCTD14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...