Seroatlas · Human Serome Atlas

NDUFC1

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Also known as: KFYI, NDUC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43677
Gene: NDUFC1
Ensembl: ENSG00000109390
Chromosome: 4
Canonical length: 76 aa
Protein class: Metabolic proteins, Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

76 residues, UniProt reviewed canonical sequence.

>O43677|NDUFC1
     1  MAPSALLRPL SRLLAPARLP SGPSVRSKFY VREPPNAKPD WLKVGFTLGT TVFLWIYLIK
    61  QHNEDILEYK RRNGLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDUFC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 251 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 251 nTPM
tongue: 149 nTPM
heart muscle: 78 nTPM
kidney: 27 nTPM
liver: 23 nTPM
duodenum: 22 nTPM

Single-cell type

late primary spermatocytes: 966 nCPM
parietal cells: 857 nCPM
megakaryocytes: 661 nCPM
esophageal suprabasal cells: 620 nCPM
esophageal apical cells: 579 nCPM
hepatocytes: 486 nCPM

Immune cell

basophil: 26 nTPM
T-reg: 18 nTPM
plasmacytoid DC: 16 nTPM
naive B-cell: 16 nTPM
non-classical monocyte: 14 nTPM
eosinophil: 13 nTPM

Brain region

cerebellum: 24 nTPM
white matter: 24 nTPM
pons: 23 nTPM
choroid plexus: 23 nTPM
cerebral cortex: 23 nTPM
midbrain: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0.1
gnomAD missense Z: -0.65
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

NADH dehydrogenase (ubiquinone) activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

NADH-ubiquinone oxidoreductase 1 subunit C1
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDUFC1 as an antibody target. Whether an autoantibody or antibody against NDUFC1 could matter depends on whether native NDUFC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDUFC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDUFC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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