Seroatlas · Human Serome Atlas

NDUFB2

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

Also known as: AGGG, CI-AGGG, NDUB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95178
Gene
NDUFB2
Ensembl
ENSG00000090266
Chromosome
7
Canonical length
105 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

105 residues, UniProt reviewed canonical sequence.

>O95178|NDUFB2
     1  MSALTRLASF ARVGGRLFRS GCARTAGDGG VRHAGGGVHI EPRYRQFPQL TRSQVFQSEF
    61  FSGLMWFWIL WRFWHDSEEV LGHFPYPDPS QWTDEELGIP PDDED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDUFB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
908 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 908 nTPM
  • tongue: 851 nTPM
  • skeletal muscle: 783 nTPM
  • kidney: 537 nTPM
  • choroid plexus: 478 nTPM
  • basal ganglia: 415 nTPM

Single-cell type

  • parietal cells: 1,420 nCPM
  • hepatocytes: 1,216 nCPM
  • early spermatids: 1,117 nCPM
  • esophageal suprabasal cells: 951 nCPM
  • hofbauer cells: 832 nCPM
  • colonocytes: 788 nCPM

Immune cell

  • total PBMC: 1,800 nTPM
  • myeloid DC: 1,165 nTPM
  • intermediate monocyte: 1,121 nTPM
  • classical monocyte: 1,050 nTPM
  • non-classical monocyte: 1,044 nTPM
  • memory B-cell: 1,015 nTPM

Brain region

  • thalamus: 215 nTPM
  • white matter: 209 nTPM
  • cerebellum: 209 nTPM
  • choroid plexus: 202 nTPM
  • spinal cord: 196 nTPM
  • hypothalamus: 192 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.86
gnomAD pLI
0
gnomAD missense Z
-0.13
DepMap mean gene effect
-0.28
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, animal type
  • NADH dehydrogenase 1 beta subcomplex subunit 2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDUFB2 as an antibody target. Whether an autoantibody or antibody against NDUFB2 could matter depends on whether native NDUFB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDUFB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDUFB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NDUFB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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