NDUFB1
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
Also known as: CI-MNLL, MNLL, NDUB1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O75438
- Gene
- NDUFB1
- Ensembl
- ENSG00000183648
- Chromosome
- 14
- Canonical length
- 58 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nuclear speckles,Mitochondria
OverviewNCBI Gene
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrial inner membrane and nuclear speck. Part of respiratory chain complex I. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
58 residues, UniProt reviewed canonical sequence.
>O75438|NDUFB1
1 MVNLLQIVRD HWVHVLVPMG FVIGCYLDRK SDERLTAFRN KSMLFKRELQ PSEEVTWKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NDUFB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 1,308 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 1,308 nTPM
- tongue: 983 nTPM
- skeletal muscle: 925 nTPM
- choroid plexus: 680 nTPM
- kidney: 635 nTPM
- amygdala: 574 nTPM
Single-cell type
- parietal cells: 2,816 nCPM
- hepatocytes: 1,858 nCPM
- gastric chief cells: 897 nCPM
- gastric progenitor cells: 806 nCPM
- enterocytes: 746 nCPM
- megakaryocytes: 692 nCPM
Immune cell
- neutrophil: 730 nTPM
- total PBMC: 657 nTPM
- plasmacytoid DC: 607 nTPM
- classical monocyte: 571 nTPM
- myeloid DC: 511 nTPM
- basophil: 459 nTPM
Brain region
- choroid plexus: 172 nTPM
- hypothalamus: 155 nTPM
- white matter: 128 nTPM
- cerebellum: 127 nTPM
- medulla oblongata: 121 nTPM
- cerebral cortex: 118 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.9
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.21
- DepMap mean gene effect
- -0.69
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- aerobic respiration
- mitochondrial electron transport, NADH to ubiquinone
- proton motive force-driven mitochondrial ATP synthesis
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1, NDUB1
- MNLL subunit
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NDUFB1 as an antibody target. Whether an autoantibody or antibody against NDUFB1 could matter depends on whether native NDUFB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NDUFB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NDUFB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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