Seroatlas · Human Serome Atlas

NDUFA5

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

Also known as: B13, CI-13kB, CI-13KD-B, NDUA5_HUMAN, NUFM, UQOR13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16718
Gene
NDUFA5
Ensembl
ENSG00000128609
Chromosome
7
Canonical length
116 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This nuclear gene encodes a conserved protein that comprises the B13 subunit of complex I of the mitochondrial respiratory chain. The encoded protein localizes to the inner mitochondrial membrane, where it is thought to aid in the transfer of electrons from NADH to ubiquinone. Alternative splicing results in multiple transcript variants. There are numerous pseudogenes of this gene on chromosomes 1, 3, 6, 8, 9, 11, 12, and 16. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>Q16718|NDUFA5
     1  MAGVLKKTTG LVGLAVCNTP HERLRILYTK ILDVLEEIPK NAAYRKYTEQ ITNEKLAMVK
    61  AEPDVKKLED QLQGGQLEEV ILQAEHELNL ARKMREWKLW EPLVEEPPAD QWKWPI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDUFA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
377 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 377 nTPM
  • skeletal muscle: 267 nTPM
  • heart muscle: 202 nTPM
  • kidney: 163 nTPM
  • parathyroid gland: 160 nTPM
  • cerebral cortex: 159 nTPM

Single-cell type

  • parietal cells: 1,025 nCPM
  • late primary spermatocytes: 404 nCPM
  • early spermatids: 349 nCPM
  • platelets: 318 nCPM
  • megakaryocytes: 260 nCPM
  • thymic myoid cells: 257 nCPM

Immune cell

  • total PBMC: 60 nTPM
  • basophil: 58 nTPM
  • T-reg: 56 nTPM
  • MAIT T-cell: 56 nTPM
  • non-classical monocyte: 55 nTPM
  • naive CD8 T-cell: 54 nTPM

Brain region

  • hypothalamus: 104 nTPM
  • cerebral cortex: 102 nTPM
  • pons: 84 nTPM
  • basal ganglia: 84 nTPM
  • hippocampal formation: 83 nTPM
  • midbrain: 82 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.37
gnomAD pLI
0
gnomAD missense Z
0.2
DepMap mean gene effect
-0.29
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
  • ETC complex I subunit conserved region

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NDUFA5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDUFA5 as an antibody target. Whether an autoantibody or antibody against NDUFA5 could matter depends on whether native NDUFA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDUFA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDUFA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NDUFA5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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