Seroatlas · Human Serome Atlas

NDUFA4L2

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

Also known as: COXFA4L2, FLJ26118, MISTRH, NUA4L_HUMAN, NUOMS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRX3
Gene
NDUFA4L2
Ensembl
ENSG00000185633
Chromosome
12
Canonical length
87 aa
Protein class
Predicted membrane proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

87 residues, UniProt reviewed canonical sequence.

>Q9NRX3|NDUFA4L2
     1  MAGASLGARF YRQIKRHPGI IPMIGLICLG MGSAALYLLR LALRSPDVCW DRKNNPEPWN
    61  RLSPNDQYKF LAVSTDYKKL KKDRPDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDUFA4L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
405 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 405 nTPM
  • esophagus: 399 nTPM
  • skin: 262 nTPM
  • vagina: 244 nTPM
  • heart muscle: 235 nTPM
  • cervix: 203 nTPM

Single-cell type

  • esophageal apical cells: 6,356 nCPM
  • esophageal suprabasal cells: 1,422 nCPM
  • pericytes: 670 nCPM
  • müller glia: 318 nCPM
  • vascular smooth muscle cells: 317 nCPM
  • suprabasal keratinocytes: 295 nCPM

Immune cell

  • T-reg: 0.9 nTPM
  • memory B-cell: 0.6 nTPM
  • naive CD4 T-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • pons: 55 nTPM
  • white matter: 44 nTPM
  • thalamus: 41 nTPM
  • cerebral cortex: 38 nTPM
  • medulla oblongata: 38 nTPM
  • midbrain: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.36
gnomAD pLI
0.09
gnomAD missense Z
-0.51
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDUFA4L2 as an antibody target. Whether an autoantibody or antibody against NDUFA4L2 could matter depends on whether native NDUFA4L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDUFA4L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDUFA4L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NDUFA4L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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