Seroatlas · Human Serome Atlas

NDRG3

Protein NDRG3

Also known as: NDRG3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UGV2
Gene: NDRG3
Ensembl: ENSG00000101079
Chromosome: 20
Canonical length: 375 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to be involved in decidualization and signal transduction. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q9UGV2|NDRG3
     1  MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETTHG VVHVTIRGLP KGNRPVILTY
    61  HDIGLNHKSC FNAFFNFEDM QEITQHFAVC HVDAPGQQEG APSFPTGYQY PTMDELAEML
   121  PPVLTHLSLK SIIGIGVGAG AYILSRFALN HPELVEGLVL INVDPCAKGW IDWAASKLSG
   181  LTTNVVDIIL AHHFGQEELQ ANLDLIQTYR MHIAQDINQD NLQLFLNSYN GRRDLEIERP
   241  ILGQNDNKSK TLKCSTLLVV GDNSPAVEAV VECNSRLNPI NTTLLKMADC GGLPQVVQPG
   301  KLTEAFKYFL QGMGYIPSAS MTRLARSRTH STSSSLGSGE SPFSRSVTSN QSDGTQESCE
   361  SPDVLDRHQT MEVSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDRG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 148 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 148 nTPM
retina: 106 nTPM
cerebral cortex: 95 nTPM
testis: 71 nTPM
hippocampal formation: 62 nTPM
basal ganglia: 61 nTPM

Single-cell type

early spermatids: 1,129 nCPM
late spermatids: 458 nCPM
late primary spermatocytes: 419 nCPM
cone photoreceptor cells: 226 nCPM
rod photoreceptor cells: 194 nCPM
myonuclei: 154 nCPM

Immune cell

NK-cell: 27 nTPM
T-reg: 18 nTPM
MAIT T-cell: 18 nTPM
memory CD4 T-cell: 17 nTPM
gdT-cell: 17 nTPM
memory CD8 T-cell: 16 nTPM

Brain region

pons: 123 nTPM
cerebral cortex: 122 nTPM
cerebellum: 115 nTPM
hippocampal formation: 107 nTPM
thalamus: 100 nTPM
medulla oblongata: 100 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.37
gnomAD missense Z: 1.14
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDRG3 as an antibody target. Whether an autoantibody or antibody against NDRG3 could matter depends on whether native NDRG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDRG3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDRG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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