Seroatlas · Human Serome Atlas

NDNF

Protein NDNF

Also known as: C4orf31, FLJ23191, NDNF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TB73
Gene
NDNF
Ensembl
ENSG00000173376
Chromosome
4
Canonical length
568 aa
Protein class
Disease related genes, Human disease related genes, Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Predicted to enable heparin binding activity. Involved in several processes, including cellular response to hypoxia; negative regulation of apoptotic process; and nitric oxide mediated signal transduction. Located in extracellular region. Is active in extracellular space. Implicated in hypogonadotropic hypogonadism. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

568 residues, UniProt reviewed canonical sequence.

>Q8TB73|NDNF
     1  MVLLHWCLLW LLFPLSSRTQ KLPTRDEELF QMQIRDKAFF HDSSVIPDGA EISSYLFRDT
    61  PKRYFFVVEE DNTPLSVTVT PCDAPLEWKL SLQELPEDRS GEGSGDLEPL EQQKQQIINE
   121  EGTELFSYKG NDVEYFISSS SPSGLYQLDL LSTEKDTHFK VYATTTPESD QPYPELPYDP
   181  RVDVTSLGRT TVTLAWKPSP TASLLKQPIQ YCVVINKEHN FKSLCAVEAK LSADDAFMMA
   241  PKPGLDFSPF DFAHFGFPSD NSGKERSFQA KPSPKLGRHV YSRPKVDIQK ICIGNKNIFT
   301  VSDLKPDTQY YFDVFVVNIN SNMSTAYVGT FARTKEEAKQ KTVELKDGKI TDVFVKRKGA
   361  KFLRFAPVSS HQKVTFFIHS CLDAVQIQVR RDGKLLLSQN VEGIQQFQLR GKPKAKYLVR
   421  LKGNKKGASM LKILATTRPT KQSFPSLPED TRIKAFDKLR TCSSATVAWL GTQERNKFCI
   481  YKKEVDDNYN EDQKKREQNQ CLGPDIRKKS EKVLCKYFHS QNLQKAVTTE TIKGLQPGKS
   541  YLLDVYVIGH GGHSVKYQSK VVKTRKFC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDNF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
100 nTPM

Expression across tissuesHPA

Tissue

  • lung: 100 nTPM
  • placenta: 57 nTPM
  • retina: 53 nTPM
  • ovary: 40 nTPM
  • kidney: 25 nTPM
  • fallopian tube: 19 nTPM

Single-cell type

  • podocytes: 471 nCPM
  • early spermatids: 305 nCPM
  • late spermatids: 292 nCPM
  • alveolar cells type 1: 143 nCPM
  • corticotrophs: 143 nCPM
  • choroid plexus epithelial cells: 136 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 33 nTPM
  • midbrain: 28 nTPM
  • choroid plexus: 21 nTPM
  • medulla oblongata: 20 nTPM
  • spinal cord: 17 nTPM
  • white matter: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NDNF.

Disease | AllUniProt

Conditions NDNF is implicated in, by any mechanism.

  • Hypogonadotropic hypogonadism 25 with anosmia (HH25) MIM:618841

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 77 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hypogonadotropic hypogonadism 25 with anosmia
  • See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.38
gnomAD missense Z
0.48
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDNF as an antibody target. Whether an autoantibody or antibody against NDNF could matter depends on whether native NDNF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDNF is annotated as secreted, so native NDNF circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NDNF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NDNF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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