Seroatlas · Human Serome Atlas

NCR3LG1

Natural cytotoxicity triggering receptor 3 ligand 1

Also known as: B7-H6, DKFZp686O24166, NR3L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q68D85
Gene
NCR3LG1
Ensembl
ENSG00000188211
Chromosome
11
Canonical length
454 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>Q68D85|NCR3LG1
     1  MTWRAAASTC AALLILLWAL TTEGDLKVEM MAGGTQITPL NDNVTIFCNI FYSQPLNITS
    61  MGITWFWKSL TFDKEVKVFE FFGDHQEAFR PGAIVSPWRL KSGDASLRLP GIQLEEAGEY
   121  RCEVVVTPLK AQGTVQLEVV ASPASRLLLD QVGMKENEDK YMCESSGFYP EAINITWEKQ
   181  TQKFPHPIEI SEDVITGPTI KNMDGTFNVT SCLKLNSSQE DPGTVYQCVV RHASLHTPLR
   241  SNFTLTAARH SLSETEKTDN FSIHWWPISF IGVGLVLLIV LIPWKKICNK SSSAYTPLKC
   301  ILKHWNSFDT QTLKKEHLIF FCTRAWPSYQ LQDGEAWPPE GSVNINTIQQ LDVFCRQEGK
   361  WSEVPYVQAF FALRDNPDLC QCCRIDPALL TVTSGKSIDD NSTKSEKQTP REHSDAVPDA
   421  PILPVSPIWE PPPATTSTTP VLSSQPPTLL LPLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCR3LG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
7 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 7 nTPM
  • cerebellum: 6 nTPM
  • rectum: 4.8 nTPM
  • duodenum: 4.2 nTPM
  • colon: 3.2 nTPM
  • small intestine: 3.2 nTPM

Single-cell type

  • epicardial cells: 114 nCPM
  • choroid plexus epithelial cells: 51 nCPM
  • retinal ganglion cells: 50 nCPM
  • monocytes: 41 nCPM
  • neutrophils: 29 nCPM
  • brain excitatory neurons: 27 nCPM

Immune cell

  • MAIT T-cell: 0.4 nTPM
  • classical monocyte: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 23 nTPM
  • cerebellum: 22 nTPM
  • choroid plexus: 20 nTPM
  • white matter: 14 nTPM
  • hypothalamus: 13 nTPM
  • basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
1.69
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCR3LG1 as an antibody target. Whether an autoantibody or antibody against NCR3LG1 could matter depends on whether native NCR3LG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCR3LG1 is annotated at the cell surface, where native NCR3LG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NCR3LG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NCR3LG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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