Seroatlas · Human Serome Atlas

NCOA5

Nuclear receptor coactivator 5

Also known as: bA465L10.6, CIA, NCOA5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCD5
Gene: NCOA5
Ensembl: ENSG00000124160
Chromosome: 20
Canonical length: 579 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Actin filaments

OverviewNCBI Gene

This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>Q9HCD5|NCOA5
     1  MNTAPSRPSP TRRDPYGFGD SRDSRRDRSP IRGSPRREPR DGRNGRDARD SRDIRDPRDL
    61  RDHRHSRDLR DHRDSRSVRD VRDVRDLRDF RDLRDSRDFR DQRDPMYDRY RDMRDSRDPM
   121  YRREGSYDRY LRMDDYCRRK DDSYFDRYRD SFDGRGPPGP ESQSRAKERL KREERRREEL
   181  YRQYFEEIQR RFDAERPVDC SVIVVNKQTK DYAESVGRKV RDLGMVVDLI FLNTEVSLSQ
   241  ALEDVSRGGS PFAIVITQQH QIHRSCTVNI MFGTPQEHRN MPQADAMVLV ARNYERYKNE
   301  CREKEREEIA RQAAKMADEA ILQERERGGP EEGVRGGHPP AIQSLINLLA DNRYLTAEET
   361  DKIINYLRER KERLMRSSTD SLPGPISRQP LGATSGASLK TQPSSQPLQS GQVLPSATPT
   421  PSAPPTSQQE LQAKILSLFN SGTVTANSSS ASPSVAAGNT PNQNFSTAAN SQPQQRSQAS
   481  GNQPPSILGQ GGSAQNMGPR PGAPSQGLFG QPSSRLAPAS NMTSQRPVSS TGINFDNPSV
   541  QKALDTLIQS GPALSHLVSQ TTAQMGQPQA PMGSYQRHY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCOA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 30 nTPM
ovary: 27 nTPM
testis: 25 nTPM
thymus: 25 nTPM
cervix: 24 nTPM
endometrium: 24 nTPM

Single-cell type

microglia: 112 nCPM
somatotrophs: 94 nCPM
lactotrophs: 82 nCPM
choroid plexus epithelial cells: 80 nCPM
thymic myoid cells: 72 nCPM
thyrotrophs: 66 nCPM

Immune cell

plasmacytoid DC: 22 nTPM
naive B-cell: 18 nTPM
MAIT T-cell: 16 nTPM
memory CD4 T-cell: 14 nTPM
memory CD8 T-cell: 14 nTPM
eosinophil: 13 nTPM

Brain region

cerebellum: 32 nTPM
cerebral cortex: 24 nTPM
hypothalamus: 24 nTPM
choroid plexus: 23 nTPM
white matter: 23 nTPM
basal ganglia: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NCOA5.

Disease | ImmuneIEDB

Conditions an epitope on NCOA5 was assayed in.

glioblastoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 0.99
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Anticodon-binding domain superfamily
Nuclear receptor coactivator/corepressor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NCOA5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCOA5 as an antibody target. Whether an autoantibody or antibody against NCOA5 could matter depends on whether native NCOA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCOA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCOA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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