Seroatlas · Human Serome Atlas

NCMAP

Noncompact myelin-associated protein

Also known as: C1orf130, FLJ42528, MP11, NCMAP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T1S8
Gene: NCMAP
Ensembl: ENSG00000184454
Chromosome: 1
Canonical length: 102 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be a structural constituent of myelin sheath. Predicted to be involved in peripheral nervous system myelin formation and positive regulation of myelination. Predicted to be located in plasma membrane. Predicted to be active in Schmidt-Lanterman incisure and paranode region of axon. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

102 residues, UniProt reviewed canonical sequence.

>Q5T1S8|NCMAP
     1  MTTATPLGDT TFFSLNMTTR GEDFLYKSSG AIVAAVVVVV IIIFTVVLIL LKMYNRKMRT
    61  RRELEPKGPK PTAPSAVGPN SNGSQHPATV TFSPVDVQVE TR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCMAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

pancreas: 8.1 nTPM
salivary gland: 7.3 nTPM
gallbladder: 6.9 nTPM
duodenum: 4.7 nTPM
stomach: 4.6 nTPM
liver: 4.3 nTPM

Single-cell type

tuft cells: 646 nCPM
pancreatic duct cells: 159 nCPM
breast lactating cells: 79 nCPM
epididymal efferent duct absorptive cells: 76 nCPM
schwann cells: 57 nCPM
parietal cells: 57 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.3 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

white matter: 6.8 nTPM
cerebellum: 6.1 nTPM
cerebral cortex: 5.5 nTPM
pons: 5.5 nTPM
medulla oblongata: 4.9 nTPM
hypothalamus: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0.04
gnomAD missense Z: 0.18
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of myelin sheath

Cellular components

Protein domainsUniProt · Pfam · InterPro

Noncompact myelin-associated protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCMAP as an antibody target. Whether an autoantibody or antibody against NCMAP could matter depends on whether native NCMAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCMAP is annotated at the cell surface, where native NCMAP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NCMAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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