NCKAP5

Protein identityUniProt · HPA

UniProt accession

O14513

Gene

NCKAP5

Ensembl

ENSG00000176771

Chromosome

2

Canonical length

1909 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoli,Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be involved in microtubule bundle formation and microtubule depolymerization. Predicted to be active in microtubule plus-end. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1909 residues, UniProt reviewed canonical sequence.

>O14513|NCKAP5
     1  MEGKRQLEKR DFGKRLSLDS SLVEYMDSNK YIEHLLTQLE EQHRSLWREK LAVARLQREV
    61  AQRTSEGAMH EKLIHELEEE RHLRLQSEKR LQEVTLESER NRIQMRSLQQ QFSRMEETVR
   121  NLLQSQGSPE QKKEETVNIM VYQEKLSEEE RKHKEALEDL HMVVDEDSRS ESSSTDEGKE
   181  KTKLLLERLK ALEAENSALA LENENQREQY ERCLDEVANQ VVQALLTQKD LREECVKLKT
   241  RVFDLEQQNR TLSILFQQRV RPTSDLLLQK LHSRLLDLSS GDLLSEVERN RSLTQSRTDA
   301  EVHEHQLNTK SALKCPGLGA VIPGHLCPRN SYSSSSELSL SSTCSEYSSG SSYTWHDGKN
   361  LRKRQSSQNW DKRLSIDSSL PSGFASPTNE LPPTRIKESH ILEGLRKLQK RKVLLEPPSV
   421  ITKWGYKDCM NSNEGIYSPG IKSSSLKEYP PCKTADLGSP CKEPHKTFVY DLDSHVDADD
   481  DPSTLALLQA VPNQSCRPHG SKLTHSVSDS LFGWETNRKH FLEGTSSVYP KERPEKLTSC
   541  ASSCPLEMKL CPSVQTPQVQ RERGPQGQGH GRMALNLQLS DTDDNETFDE LHIESSDEKS
   601  PSDVSLAADT DKSVENLDVL VGFGKSLCGS PEEEEKQVPI PSETRPKTFS FIKQQRVVKR
   661  TSSEECVTVI FDAEDGEPIE FSSHQTGVVT VTRNEISINS TPAGPKAEHT ELLPQGIACL
   721  QPRAAARDYT FFKRSEEDTE KNIPKDNVDN VPRVSTESFS SRTVTQNPQQ QKLVKPTHNI
   781  SCQSNSRSSA PMGIYQKQNL TKIPPRGKSS PQKSKLMEPE ATTLLPSSGL VTLEKSPALA
   841  PGKLSRFMKT ESSGPLFELR SDPHIPKHSA QLPHSSRMPS RRDWVQCPKS QTPGSRSRPA
   901  IESSDSGEPP TRDEHCGSGP EAGVKSPSPP PPPGRSVSLL ARPSYDYSPA PSSTKSETRV
   961  PSETARTPFK SPLLKGISAP VISSNPATTE VQRKKPSVAF KKPIFTHPMP SPEAVIQTRC
  1021  PAHAPSSSFT VMALGPPKVS PKRGVPKTSP RQTLGTPQRD IGLQTPRISP STHEPLEMTS
  1081  SKSVSPGRKG QLNDSASTPP KPSFLGVNES PSSQVSSSSS SSSPAKSHNS PHGCQSAHEK
  1141  GLKTRLPVGL KVLMKSPQLL RKSSTVPGKH EKDSLNEASK SSVAVNKSKP EDSKNPASME
  1201  ITAGERNVTL PDSQAQGSLA DGLPLETALQ EPLESSIPGS DGRDGVDNRS MRRSLSSSKP
  1261  HLKPALGMNG AKARSHSFST HSGDKPSTPP IEGSGKVRTQ IITNTAERGN SLTRQNSSTE
  1321  SSPNKAPSAP MLESLPSVGR PSGHPSSGKG SLGSSGSFSS QHGSPSKLPL RIPPKSEGLL
  1381  IPPGKEDQQA FTQGECPSAN VAVLGEPGSD RRSCPPTPTD CPEALQSPGR TQHPSTFETS
  1441  STSKLETSGR HPDASATATD AVSSEAPLSP TIEEKVMLCI QENVEKGQVQ TKPTSVEAKQ
  1501  KPGPSFASWF GFRKSRLPAL SSRKMDISKT KVEKKDAKVL GFGNRQLKSE RKKEKKKPEL
  1561  QCETENELIK DTKSADNPDG GLQSKNNRRT PQDIYNQLKI EPRNRHSPVA CSTKDTFMTE
  1621  LLNRVDKKAA PQTESGSSNA SCRNVLKGSS QGSCLIGSSI STQGNHKKNM KIKADMEVPK
  1681  DSLVKEANEN LQEDEDDAVA DSVFQSHIIE SNCQMRTLDS GIGTFPLPDS GNRSTGRYLC
  1741  QPDSPEDAEP LLPLQSALSA VSSMRAQTLE REVPSSTDGQ RPADSAIVHS TSDPIMTARG
  1801  MRPLQSRLPK PASSGKVSSQ KQNEAEPRPQ TCSSFGYAED PMASQPLPDW GSEVAATGTQ
  1861  DKAPRMCTYS ASGGSNSDSD LDYGDNGFGA GRGQLVKALK SAAPEIETT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCKAP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.65

Highest tissue expression

11 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.45

gnomAD pLI

0

gnomAD missense Z

-0.37

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• microtubule bundle formation
• microtubule depolymerization

Cellular components

• microtubule plus-end

Protein domainsUniProt · Pfam · InterPro

• Nck-associated protein 5-like
• Nck-associated protein 5, C-terminal
• Nck-associated protein 5, Peripheral clock protein

KeywordsUniProt

• Coiled coil

InteractionsUniProt · HPA

Protein binding partners of NCKAP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• APC