Seroatlas · Human Serome Atlas

NCBP2AS2

Protein NCBP2AS2

Also known as: HIAR, KRASIM, NCAS2_HUMAN, NCBP2-AS2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q69YL0
Gene
NCBP2AS2
Ensembl
ENSG00000270170
Chromosome
3
Canonical length
99 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

99 residues, UniProt reviewed canonical sequence.

>Q69YL0|NCBP2AS2
     1  MVLRRLLAAL LHSPQLVERL SESRPIRRAA QLTAFALLQA QLRGQDAARR LQDLAAGPVG
    61  SLCRRAERFR DAFTQELRRG LRGRSGPPPG SQRGPGANI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCBP2AS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 46 nTPM
  • cerebral cortex: 38 nTPM
  • bone marrow: 36 nTPM
  • basal ganglia: 34 nTPM
  • choroid plexus: 34 nTPM
  • tongue: 33 nTPM

Single-cell type

  • esophageal basal cells: 113 nCPM
  • esophageal suprabasal cells: 92 nCPM
  • colonocytes: 81 nCPM
  • gastric progenitor cells: 72 nCPM
  • enteric transient amplifying cells: 71 nCPM
  • epididymal principal cells: 71 nCPM

Immune cell

  • naive CD4 T-cell: 142 nTPM
  • plasmacytoid DC: 129 nTPM
  • NK-cell: 127 nTPM
  • naive B-cell: 124 nTPM
  • classical monocyte: 121 nTPM
  • T-reg: 119 nTPM

Brain region

  • hypothalamus: 39 nTPM
  • cerebellum: 36 nTPM
  • cerebral cortex: 35 nTPM
  • pons: 34 nTPM
  • thalamus: 34 nTPM
  • basal ganglia: 33 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein NCBP2AS2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCBP2AS2 as an antibody target. Whether an autoantibody or antibody against NCBP2AS2 could matter depends on whether native NCBP2AS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCBP2AS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCBP2AS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NCBP2AS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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