NBL1

Protein identityUniProt · HPA

UniProt accession

P41271

Gene

NBL1

Ensembl

ENSG00000158747

Chromosome

1

Canonical length

181 aa

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted in other tissues

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

181 residues, UniProt reviewed canonical sequence.

>P41271|NBL1
     1  MMLRVLVGAV LPAMLLAAPP PINKLALFPD KSAWCEAKNI TQIVGHSGCE AKSIQNRACL
    61  GQCFSYSVPN TFPQSTESLV HCDSCMPAQS MWEIVTLECP GHEEVPRVDK LVEKILHCSC
   121  QACGKEPSHE GLSVYVQGED GPGSQPGTHP HPHPHPHPGG QTPEPEDPPG APHTEEEGAE
   181  D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NBL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.53

Highest tissue expression

590 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.02

gnomAD pLI

0.06

gnomAD missense Z

1.52

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• determination of dorsal identity
• negative regulation of BMP signaling pathway
• negative regulation of monocyte chemotaxis
• nervous system development
• neuron projection morphogenesis
• positive regulation of neuron differentiation
• sequestering of BMP from receptor via BMP binding
• sequestering of BMP in extracellular matrix

Molecular functions

• BMP binding
• identical protein binding
• morphogen activity
• receptor ligand activity

Cellular components

• extracellular space

Protein domainsUniProt · Pfam · InterPro

• DAN
• Cystine knot, C-terminal
• Cystine-knot cytokine
• DAN domain
• Neuroblastoma suppressor of tumourigenicity 1

KeywordsUniProt

• Disulfide bond
• Secreted
• Signal
• Tumor suppressor

InteractionsUniProt · HPA

Protein binding partners of NBL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• UBQLN1