Seroatlas · Human Serome Atlas

NAPEPLD

N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D

Also known as: C7orf18, FMP30, NAPE-PLD, NAPEP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6IQ20
Gene
NAPEPLD
Ensembl
ENSG00000161048
Chromosome
7
Canonical length
393 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM, Oct 2008]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>Q6IQ20|NAPEPLD
     1  MDENESNQSL MTSSQYPKEA VRKRQNSARN SGASDSSRFS RKSFKLDYRL EEDVTKSKKG
    61  KDGRFVNPWP TWKNPSIPNV LRWLIMEKDH SSVPSSKEEL DKELPVLKPY FITNPEEAGV
   121  REAGLRVTWL GHATVMVEMD ELIFLTDPIF SSRASPSQYM GPKRFRRSPC TISELPPIDA
   181  VLISHNHYDH LDYNSVIALN ERFGNELRWF VPLGLLDWMQ KCGCENVIEL DWWEENCVPG
   241  HDKVTFVFTP SQHWCKRTLM DDNKVLWGSW SVLGPWNRFF FAGDTGYCPA FEEIGKRFGP
   301  FDLAAIPIGA YEPRWFMKYQ HVDPEEAVRI HTDVQTKKSM AIHWGTFALA NEHYLEPPVK
   361  LNEALERYGL NAEDFFVLKH GESRYLNNDD ENF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAPEPLD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 14 nTPM
  • duodenum: 14 nTPM
  • cerebral cortex: 11 nTPM
  • stomach: 9.3 nTPM
  • small intestine: 9.1 nTPM
  • thyroid gland: 7.7 nTPM

Single-cell type

  • oligodendrocytes: 263 nCPM
  • podocytes: 259 nCPM
  • oligodendrocyte progenitor cells: 187 nCPM
  • loop of henle epithelial cells: 146 nCPM
  • renal collecting duct principal cells: 131 nCPM
  • early spermatids: 111 nCPM

Immune cell

  • memory B-cell: 4.6 nTPM
  • naive B-cell: 4.6 nTPM
  • naive CD4 T-cell: 4.4 nTPM
  • eosinophil: 3.7 nTPM
  • memory CD8 T-cell: 3.4 nTPM
  • naive CD8 T-cell: 3.2 nTPM

Brain region

  • white matter: 45 nTPM
  • cerebral cortex: 35 nTPM
  • basal ganglia: 34 nTPM
  • thalamus: 32 nTPM
  • amygdala: 29 nTPM
  • cerebellum: 28 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NAPEPLD.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 78 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
0.31
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAPEPLD as an antibody target. Whether an autoantibody or antibody against NAPEPLD could matter depends on whether native NAPEPLD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAPEPLD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAPEPLD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NAPEPLD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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