Seroatlas · Human Serome Atlas

NAP1L3

Nucleosome assembly protein 1-like 3

Also known as: MB20, MGC26312, NP1L3_HUMAN, NPL3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99457
Gene: NAP1L3
Ensembl: ENSG00000186310
Chromosome: X
Canonical length: 506 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Vesicles

OverviewNCBI Gene

This gene is intronless and encodes a member of the nucleosome assembly protein (NAP) family. This gene is linked closely to a region of genes responsible for several X-linked cognitive disability syndromes. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

506 residues, UniProt reviewed canonical sequence.

>Q99457|NAP1L3
     1  MAEADFKMVS EPVAHGVAEE EMASSTSDSG EESDSSSSSS STSDSSSSSS TSGSSSGSGS
    61  SSSSSGSTSS RSRLYRKKRV PEPSRRARRA PLGTNFVDRL PQAVRNRVQA LRNIQDECDK
   121  VDTLFLKAIH DLERKYAELN KPLYDRRFQI INAEYEPTEE ECEWNSEDEE FSSDEEVQDN
   181  TPSEMPPLEG EEEENPKENP EVKAEEKEVP KEIPEVKDEE KEVPKEIPEV KAEEKADSKD
   241  CMEATPEVKE DPKEVPQVKA DDKEQPKATE AKARAAVRET HKRVPEERLQ DSVDLKRARK
   301  GKPKREDPKG IPDYWLIVLK NVDKLGPMIQ KYDEPILKFL SDVSLKFSKP GQPVSYTFEF
   361  HFLPNPYFRN EVLVKTYIIK AKPDHNDPFF SWGWEIEDCK GCKIDWRRGK DVTVTTTQSR
   421  TTATGEIEIQ PRVVPNASFF NFFSPPEIPM IGKLEPREDA ILDEDFEIGQ ILHDNVILKS
   481  IYYYTGEVNG TYYQFGKHYG NKKYRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAP1L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 120 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 120 nTPM
cerebral cortex: 112 nTPM
hypothalamus: 108 nTPM
amygdala: 60 nTPM
basal ganglia: 60 nTPM
hippocampal formation: 54 nTPM

Single-cell type

other brain neurons: 84 nCPM
brain inhibitory neurons: 64 nCPM
brain excitatory neurons: 47 nCPM
retinal amacrine cells: 41 nCPM
retinal horizontal cells: 38 nCPM
corticotrophs: 30 nCPM

Immune cell

naive CD4 T-cell: 4.1 nTPM
NK-cell: 3.1 nTPM
naive CD8 T-cell: 2.9 nTPM
memory CD4 T-cell: 2.6 nTPM
gdT-cell: 1.9 nTPM
memory CD8 T-cell: 0.9 nTPM

Brain region

cerebral cortex: 146 nTPM
basal ganglia: 128 nTPM
midbrain: 128 nTPM
hypothalamus: 126 nTPM
pons: 109 nTPM
thalamus: 93 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0.09
gnomAD missense Z: 0.49
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

nucleosome assembly

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAP1L3 as an antibody target. Whether an autoantibody or antibody against NAP1L3 could matter depends on whether native NAP1L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAP1L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAP1L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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