Seroatlas · Human Serome Atlas

NAP1L2

Nucleosome assembly protein 1-like 2

Also known as: BPX, MGC26243, NP1L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULW6
Gene
NAP1L2
Ensembl
ENSG00000186462
Chromosome
X
Canonical length
460 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this intronless gene is a member of the nucleosome assembly protein (NAP) family. The encoded protein represents a class of tissue-specific factors that interact with chromatin to regulate neuronal cell proliferation. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

460 residues, UniProt reviewed canonical sequence.

>Q9ULW6|NAP1L2
     1  MAESENRKEL SESSQEEAGN QIMVEGLGEH LERGEDAAAG LGDDGKCGEE AAAGLGEEGE
    61  NGEDTAAGSG EDGKKGGDTD EDSEADRPKG LIGYVLDTDF VESLPVKVKY RVLALKKLQT
   121  RAANLESKFL REFHDIERKF AEMYQPLLEK RRQIINAIYE PTEEECEYKS DSEDCDDEEM
   181  CHEEMYGNEE GMVHEYVDED DGYEDYYYDY AVEEEEEEEE EDDIEATGEE NKEEEDPKGI
   241  PDFWLTVLKN VDTLTPLIKK YDEPILKLLT DIKVKLSDPG EPLSFTLEFH FKPNEYFKNE
   301  LLTKTYVLKS KLAYYDPHPY RGTAIEYSTG CEIDWNEGKN VTLKTIKKKQ KHRIWGTIRT
   361  VTEDFPKDSF FNFFSPHGIT SNGRDGNDDF LLGHNLRTYI IPRSVLFFSG DALESQQEGV
   421  VREVNDAIYD KIIYDNWMAA IEEVKACCKN LEALVEDIDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAP1L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 76 nTPM
  • cerebellum: 71 nTPM
  • hypothalamus: 41 nTPM
  • hippocampal formation: 35 nTPM
  • basal ganglia: 30 nTPM
  • amygdala: 27 nTPM

Single-cell type

  • brain excitatory neurons: 37 nCPM
  • other brain neurons: 36 nCPM
  • brain inhibitory neurons: 34 nCPM
  • prostatic glandular cells: 30 nCPM
  • retinal amacrine cells: 27 nCPM
  • somatotrophs: 21 nCPM

Immune cell

  • naive CD8 T-cell: 1.3 nTPM
  • memory CD4 T-cell: 1.2 nTPM
  • gdT-cell: 1 nTPM
  • T-reg: 1 nTPM
  • memory CD8 T-cell: 0.8 nTPM
  • naive CD4 T-cell: 0.6 nTPM

Brain region

  • cerebral cortex: 116 nTPM
  • cerebellum: 70 nTPM
  • hypothalamus: 69 nTPM
  • white matter: 64 nTPM
  • basal ganglia: 58 nTPM
  • hippocampal formation: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.78
gnomAD missense Z
0.1
DepMap mean gene effect
0.16
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAP1L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAP1L2 as an antibody target. Whether an autoantibody or antibody against NAP1L2 could matter depends on whether native NAP1L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAP1L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAP1L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NAP1L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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