Seroatlas · Human Serome Atlas

NANP

N-acylneuraminate-9-phosphatase

Also known as: C20orf147, dJ694B14.3, HDHD4, MGC26833, NANP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBE9
Gene: NANP
Ensembl: ENSG00000170191
Chromosome: 20
Canonical length: 248 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nuclear membrane,Cytosol

OverviewNCBI Gene

Enables N-acylneuraminate-9-phosphatase activity. Involved in CMP-N-acetylneuraminate biosynthetic process; N-acetylneuraminate biosynthetic process; and glycosylation. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>Q8TBE9|NANP
     1  MGLSRVRAVF FDLDNTLIDT AGASRRGMLE VIKLLQSKYH YKEEAEIICD KVQVKLSKEC
    61  FHPYNTCITD LRTSHWEEAI QETKGGAANR KLAEECYFLW KSTRLQHMTL AEDVKAMLTE
   121  LRKEVRLLLL TNGDRQTQRE KIEACACQSY FDAVVVGGEQ REEKPAPSIF YYCCNLLGVQ
   181  PGDCVMVGDT LETDIQGGLN AGLKATVWIN KNGIVPLKSS PVPHYMVSSV LELPALLQSI
   241  DCKVSMST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NANP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 4.6 nTPM

Expression across tissuesHPA

Tissue

thymus: 4.6 nTPM
liver: 4.5 nTPM
kidney: 4.1 nTPM
adrenal gland: 3.7 nTPM
tongue: 3.4 nTPM
bone marrow: 3.2 nTPM

Single-cell type

erythrocyte progenitors: 22 nCPM
differentiating spermatogonia: 15 nCPM
esophageal apical cells: 14 nCPM
retinal ganglion cells: 12 nCPM
cone photoreceptor cells: 10 nCPM
early primary spermatocytes: 10 nCPM

Immune cell

myeloid DC: 3.3 nTPM
intermediate monocyte: 2.4 nTPM
classical monocyte: 2.3 nTPM
NK-cell: 2.3 nTPM
MAIT T-cell: 2 nTPM
non-classical monocyte: 1.4 nTPM

Brain region

cerebellum: 7.2 nTPM
hypothalamus: 5.5 nTPM
choroid plexus: 5.2 nTPM
midbrain: 4.8 nTPM
basal ganglia: 4.6 nTPM
cerebral cortex: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: 0.56
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

N-acylneuraminate-9-phosphatase activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

HAD hydrolase, subfamily IA
HAD superfamily
HAD-like superfamily
haloacid dehalogenase-like hydrolase
HAD-superfamily hydrolase, subfamily IA, CTE7
HAD-like hydrolase superfamily enzymes

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NANP as an antibody target. Whether an autoantibody or antibody against NANP could matter depends on whether native NANP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NANP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NANP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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