Seroatlas · Human Serome Atlas

NANOGP8

Homeobox protein NANOGP8

Also known as: NANP8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NSW7
Gene: NANOGP8
Ensembl: ENSG00000255192
Chromosome: 15
Canonical length: 305 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene represents a transcribed retrogene of the Nanog homeobox gene. The putative encoded protein may participate in reprogramming of cancer cells. In vitro studies using a recombinant protein have shown that the protein localizes to the nucleus and can promote cell proliferation, similar to the Nanog protein. [provided by RefSeq, Sep 2017]

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>Q6NSW7|NANOGP8
     1  MSVDPACPQS LPCFEESDCK ESSPMPVICG PEENYPSLQM SSAEMPHTET VSPLPSSMDL
    61  LIQDSPDSST SPKGKQPTSA ENSVAKKEDK VPVKKQKTRT VFSSTQLCVL NDRFQRQKYL
   121  SLQQMQELSN ILNLSYKQVK TWFQNQRMKS KRWQKNNWPK NSNGVTQKAS APTYPSLYSS
   181  YHQGCLVNPT GNLPMWSNQT WNNSTWSNQT QNIQSWSNHS WNTQTWCTQS WNNQAWNSPF
   241  YNCGEESLQS CMHFQPNSPA SDLEAALEAA GEGLNVIQQT TRYFSTPQTM DLFLNYSMNM
   301  QPEDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NANOGP8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

testis: 0.6 nTPM
skin: 0.3 nTPM
basal ganglia: 0.2 nTPM
bone marrow: 0.2 nTPM
endometrium: 0.2 nTPM
pancreas: 0.2 nTPM

Single-cell type

sertoli cells: 3.4 nCPM
adrenal cortex cells: 3.1 nCPM
early spermatids: 1.2 nCPM
thyrotrophs: 0.6 nCPM
cardiomyocytes: 0.5 nCPM
early primary spermatocytes: 0.5 nCPM

Immune cell

basophil: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

basal ganglia: 10 nTPM
cerebellum: 6.6 nTPM
thalamus: 4.7 nTPM
cerebral cortex: 3.7 nTPM
hypothalamus: 3.6 nTPM
white matter: 3.4 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NANOGP8 as an antibody target. Whether an autoantibody or antibody against NANOGP8 could matter depends on whether native NANOGP8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NANOGP8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NANOGP8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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