NANOGP1
Putative homeobox protein NANOG2
Also known as: NANG2_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for NANOGP1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
232 residues, UniProt reviewed canonical sequence.
>Q8N7R0|NANOGP1
1 MDLPIQDSHD SSTSPKGKQP TTAEKSATKK EDKVPVKKQK TRTVFSSTQL CVLNDRFQRQ
61 KYLSLQQMQE LSNILNLSYK QVKTWFQNQR MKSKRWQKNN WLKNSNGVTQ GCLVNPTGNL
121 PMWSNQTWNN STWSNQTQNI QSWSNHSWNT QTWCTQSWNN QAWNSPFYNC GEESLQSCMQ
181 FQPNSPASDL QAALEAAGEG LNVIQQTTRY FNTPQTMDLF LNYSMNMQPE DVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NANOGP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
OntologyGO
Biological processes
- cell differentiation
- positive regulation of cell population proliferation
- regulation of transcription by RNA polymerase II
- stem cell population maintenance
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NANOGP1 as an antibody target. Whether an autoantibody or antibody against NANOGP1 could matter depends on whether native NANOGP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NANOGP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NANOGP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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