Seroatlas · Human Serome Atlas

NANOGNB

NANOG neighbor homeobox

Also known as: NANGN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5D8
Gene: NANOGNB
Ensembl: ENSG00000205857
Chromosome: 12
Canonical length: 188 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q7Z5D8|NANOGNB
     1  MHRARWLTPV IPALWEAEAG RSRGQEIETI LANKKQSAMP WDQDPEQSTG NYSEDEQNGK
    61  QKWREEGEAG RKREREKEEK NEKELQDEQE NKRKRENEKQ KQYPEKRLVS KSLMHTLWAK
   121  FKLNRCPTIQ ESLSLSFEFD MTHKQISQWF CKTRKKYNKE MSKRKHKKKH MRWRSLCCQG
   181  WSRTPALK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NANOGNB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.2 nTPM
testis: 0.2 nTPM
appendix: 0.1 nTPM
cervix: 0.1 nTPM
pancreas: 0.1 nTPM
retina: 0.1 nTPM

Single-cell type

undifferentiated spermatogonia: 1.2 nCPM
differentiating spermatogonia: 0.9 nCPM
foveolar cells: 0.7 nCPM
mast cells: 0.6 nCPM
neutrophils: 0.5 nCPM
breast lactating cells: 0.4 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.3 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 3.1 nTPM
white matter: 2.7 nTPM
cerebral cortex: 2.6 nTPM
cerebellum: 2.5 nTPM
amygdala: 2.4 nTPM
basal ganglia: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NANOGNB as an antibody target. Whether an autoantibody or antibody against NANOGNB could matter depends on whether native NANOGNB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NANOGNB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NANOGNB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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