Seroatlas · Human Serome Atlas

NALF2

NALCN channel auxiliary factor 2

Also known as: CXorf63, FAM155B, NALF2_HUMAN, TED, TMEM28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75949
Gene: NALF2
Ensembl: ENSG00000130054
Chromosome: X
Canonical length: 472 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a product belonging to a family of proteins with unknown function. The presence of two transmembrane domains suggests that this protein is a multi-pass membrane protein. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>O75949|NALF2
     1  MFRGAWMWPG KDAAALTICC CCCCWAPRPS DKPCADSERA QRWRLSLASL LFFTVLLADH
    61  LWLCAGARPR ARELSSAMRP PWGAGRERQP VPPRAVLPLP PPPPGEPSAP PGTCGPRYSN
   121  LTKAAPAAGS RPVCGGVPEP TGLDAACTKL QSLQRLFEPT TPAPPLRPPD SLSRAPAEFP
   181  SAKKNLLKGH FRNFTLSFCD TYTVWDLLLG MDRPDSLDCS LDTLMGDLLA VVASPGSGAW
   241  EACSNCIEAY QRLDRHAQEK YDEFDLVLHK YLQAEEYSIR SCTKGCKAVY KAWLCSEYFS
   301  VTQQECQRWV PCKQYCLEVQ TRCPFILPDN EEMVYGGLPG FICTGLLDTS PKRLETKCCD
   361  VQWVSCEAKK KKFKESEAPK THQQQFHHSY FHHYHQQYHH YHPHHDPPGR VSNKPALLPV
   421  SGGSRLSPSR IRLCVLVLML LHTVVSFSSN QGGGGLGLET LPALEEGLTR EE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NALF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 35 nTPM
thyroid gland: 7.5 nTPM
cerebellum: 4.8 nTPM
seminal vesicle: 4.6 nTPM
hypothalamus: 2.9 nTPM
parathyroid gland: 2.9 nTPM

Single-cell type

cardiomyocytes: 14 nCPM
tuft cells: 12 nCPM
endometrial luminal cells: 7.9 nCPM
hepatic stellate cells: 6.5 nCPM
neuroendocrine cells: 6.2 nCPM
parietal cells: 5.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 7 nTPM
pons: 6.9 nTPM
thalamus: 6.5 nTPM
midbrain: 6.2 nTPM
cerebellum: 5.7 nTPM
cerebral cortex: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.81
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

calcium ion import across plasma membrane

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

NALCN channel auxiliary factor 1/2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NALF2 as an antibody target. Whether an autoantibody or antibody against NALF2 could matter depends on whether native NALF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NALF2 is annotated at the cell surface, where native NALF2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NALF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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