NALF1
NALCN channel auxiliary factor 1
Also known as: FAM155A, NALF1_HUMAN, NLF-1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- B1AL88
- Gene
- NALF1
- Ensembl
- ENSG00000204442
- Chromosome
- 13
- Canonical length
- 458 aa
- Protein class
- Predicted membrane proteins
OverviewNCBI Gene
Predicted to contribute to stretch-activated, monoatomic cation-selective, calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
458 residues, UniProt reviewed canonical sequence.
>B1AL88|NALF1
1 MTRGAWMCRQ YDDGLKIWLA APRENEKPFI DSERAQKWRL SLASLLFFTV LLSDHLWFCA
61 EAKLTRARDK EHQQQQRQQQ QQQQQQRQRQ QQQQQRRQQE PSWPALLASM GESSPAAQAH
121 RLLSASSSPT LPPSPGDGGG GGGKGNRGKD DRGKALFLGN SAKPVWRLET CYPQGASSGQ
181 CFTVENADAV CARNWSRGAA GGDGQEVRSK HPTPLWNLSD FYLSFCNSYT LWELFSGLSS
241 PNTLNCSLDV VLKEGGEMTT CRQCVEAYQD YDHHAQEKYE EFESVLHKYL QSEEYSVKSC
301 PEDCKIVYKA WLCSQYFEVT QFNCRKTIPC KQYCLEVQTR CPFILPDNDE VIYGGLSSFI
361 CTGLYETFLT NDEPECCDVR REEKSNNPSK GTVEKSGSCH RTSLTVSSAT RLCNSRLKLC
421 VLVLILLHTV LTASAAQNTA GLSFGGINTL EENSTNEELocalizationUniProt · AlphaFold · HPA
Whether an antibody against NALF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 8.5 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 8.5 nTPM
- hypothalamus: 5.6 nTPM
- hippocampal formation: 4.8 nTPM
- pituitary gland: 4.8 nTPM
- amygdala: 4.6 nTPM
- cerebellum: 3.7 nTPM
Single-cell type
- corticotrophs: 7,761 nCPM
- lactotrophs: 6,906 nCPM
- somatotrophs: 6,512 nCPM
- thyrotrophs: 6,009 nCPM
- gonadotrophs: 3,616 nCPM
- brain excitatory neurons: 3,413 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 22 nTPM
- hypothalamus: 22 nTPM
- hippocampal formation: 19 nTPM
- basal ganglia: 17 nTPM
- white matter: 17 nTPM
- thalamus: 16 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about NALF1.
Disease | GeneticClinVar
3 pathogenic / likely-pathogenic of 66 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.31
- gnomAD pLI
- 0.98
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NALF1 as an antibody target. Whether an autoantibody or antibody against NALF1 could matter depends on whether native NALF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NALF1 is annotated at the cell surface, where native NALF1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label NALF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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