Seroatlas · Human Serome Atlas

NACA4P

Putative nascent polypeptide-associated complex subunit alpha-like protein

Also known as: NACP4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZK3
Gene: NACA4P
Canonical length: 213 aa

OverviewNCBI Gene

No narrative summary is available for NACA4P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>Q9BZK3|NACA4P
     1  MPGEATETVP AIEQQLLQPQ AETGSGTESD SDESVPELEE QDSTQVTAQV QLVVAAEIDE
    61  EPVSKAKQRR SEKKARKARF KLGLQQVTGV TRVTIRKSKN ILFVITKPDV YKSPASDTYM
   121  VFGEAKIEDL SQEAQLAAAE KFKVQGEAVS NIQENTQTPT VQEGSEDEEV DETGVEIKDI
   181  ELVLSQANVW GAKAVRALKN SNDIVNAIME LTM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NACA4P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein targeting to membrane

Molecular functions

unfolded protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NACA4P as an antibody target. Whether an autoantibody or antibody against NACA4P could matter depends on whether native NACA4P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NACA4P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NACA4P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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