Seroatlas · Human Serome Atlas

NAB1

NGFI-A-binding protein 1

Also known as: NAB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13506
Gene
NAB1
Ensembl
ENSG00000138386
Chromosome
2
Canonical length
487 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Plasma membrane
Quaternary structure
Homomultimer

OverviewNCBI Gene

Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within endochondral ossification; nervous system development; and regulation of epidermis development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

487 residues, UniProt reviewed canonical sequence.

>Q13506|NAB1
     1  MAAALPRTLG ELQLYRILQK ANLLSYFDAF IQQGGDDVQQ LCEAGEEEFL EIMALVGMAS
    61  KPLHVRRLQK ALRDWVTNPG LFNQPLTSLP VSSIPIYKLP EGSPTWLGIS CSSYERSSNA
   121  REPHLKIPKC AATTCVQSLG QGKSDVVGSL ALQSVGESRL WQGHHATESE HSLSPADLGS
   181  PASPKESSEA LDAAAALSVA ECVERMAPTL PKSDLNEVKE LLKTNKKLAK MIGHIFEMND
   241  DDPHKEEEIR KYSAIYGRFD SKRKDGKHLT LHELTVNEAA AQLCVKDNAL LTRRDELFAL
   301  ARQISREVTY KYTYRTTKSK CGERDELSPK RIKVEDGFPD FQDSVQTLFQ QARAKSEELA
   361  ALSSQQPEKV MAKQMEFLCN QAGYERLQHA ERRLSAGLYR QSSEEHSPNG LTSDNSDGQG
   421  ERPLNLRMPN LQNRQPHHFV VDGELSRLYP SEAKSHSSES LGILKDYPHS AFTLEKKVIK
   481  TEPEDSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • skin: 63 nTPM
  • epididymis: 47 nTPM
  • retina: 38 nTPM
  • stomach: 36 nTPM
  • thyroid gland: 36 nTPM
  • liver: 35 nTPM

Single-cell type

  • epicardial cells: 134 nCPM
  • neutrophils: 130 nCPM
  • lactotrophs: 128 nCPM
  • basal keratinocytes: 111 nCPM
  • suprabasal keratinocytes: 108 nCPM
  • pituicytes/fscs: 99 nCPM

Immune cell

  • non-classical monocyte: 3.8 nTPM
  • T-reg: 3.3 nTPM
  • neutrophil: 2.9 nTPM
  • NK-cell: 2.6 nTPM
  • MAIT T-cell: 2 nTPM
  • memory CD8 T-cell: 1.7 nTPM

Brain region

  • cerebellum: 133 nTPM
  • white matter: 83 nTPM
  • cerebral cortex: 78 nTPM
  • amygdala: 69 nTPM
  • basal ganglia: 62 nTPM
  • spinal cord: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0.02
gnomAD missense Z
1.35
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAB1 as an antibody target. Whether an autoantibody or antibody against NAB1 could matter depends on whether native NAB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NAB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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