Seroatlas · Human Serome Atlas

NAAA

N-acylethanolamine-hydrolyzing acid amidase

Also known as: ASAHL, NAAA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q02083
Gene: NAAA
Ensembl: ENSG00000138744
Chromosome: 4
Canonical length: 359 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables DNA-binding transcription factor binding activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including N-acylethanolamine metabolic process; N-acylphosphatidylethanolamine metabolic process; and sphingosine metabolic process. Located in lysosome and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q02083|NAAA
     1  MRTADREARP GLPSLLLLLL AGAGLSAASP PAAPRFNVSL DSVPELRWLP VLRHYDLDLV
    61  RAAMAQVIGD RVPKWVHVLI GKVVLELERF LPQPFTGEIR GMCDFMNLSL ADCLLVNLAY
   121  ESSVFCTSIV AQDSRGHIYH GRNLDYPFGN VLRKLTVDVQ FLKNGQIAFT GTTFIGYVGL
   181  WTGQSPHKFT VSGDERDKGW WWENAIAALF RRHIPVSWLI RATLSESENF EAAVGKLAKT
   241  PLIADVYYIV GGTSPREGVV ITRNRDGPAD IWPLDPLNGA WFRVETNYDH WKPAPKEDDR
   301  RTSAIKALNA TGQANLSLEA LFQILSVVPV YNNFTIYTTV MSAGSPDKYM TRIRNPSRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAAA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

prostate: 66 nTPM
rectum: 66 nTPM
liver: 64 nTPM
spleen: 60 nTPM
colon: 58 nTPM
small intestine: 57 nTPM

Single-cell type

breast lactating cells: 322 nCPM
prostatic glandular cells: 266 nCPM
enterocytes: 233 nCPM
kupffer cells: 170 nCPM
colonocytes: 162 nCPM
monocytes: 157 nCPM

Immune cell

intermediate monocyte: 672 nTPM
non-classical monocyte: 585 nTPM
classical monocyte: 270 nTPM
total PBMC: 234 nTPM
myeloid DC: 143 nTPM
T-reg: 115 nTPM

Brain region

white matter: 27 nTPM
choroid plexus: 26 nTPM
hypothalamus: 25 nTPM
pons: 21 nTPM
midbrain: 20 nTPM
cerebellum: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: 0.82
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA-binding transcription factor binding
fatty acid amide hydrolase activity
N-acylsphingosine amidohydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
N-(long-chain-acyl)ethanolamine deacylase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAAA as an antibody target. Whether an autoantibody or antibody against NAAA could matter depends on whether native NAAA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAAA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAAA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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