Seroatlas · Human Serome Atlas

NAA38

N-alpha-acetyltransferase 38, NatC auxiliary subunit

Also known as: LSMD1, MGC14151, NAA38_HUMAN, PFAAP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRA0
Gene: NAA38
Ensembl: ENSG00000183011
Chromosome: 17
Canonical length: 125 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable RNA binding activity. Involved in negative regulation of apoptotic process. Located in cytoplasm and nucleoplasm. Part of NatC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>Q9BRA0|NAA38
     1  MAGAGPTMLL REENGCCSRR QSSSSAGDSD GEREDSAAER ARQQLEALLN KTMRIRMTDG
    61  RTLVGCFLCT DRDCNVILGS AQEFLKPSDS FSAGEPRVLG LAMVPGHHIV SIEVQRESLT
   121  GPPYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAA38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 216 nTPM

Expression across tissuesHPA

Tissue

amygdala: 216 nTPM
basal ganglia: 192 nTPM
cerebral cortex: 182 nTPM
midbrain: 179 nTPM
choroid plexus: 169 nTPM
hippocampal formation: 159 nTPM

Single-cell type

megakaryocytes: 3,078 nCPM
late spermatids: 2,249 nCPM
epicardial cells: 992 nCPM
early spermatids: 803 nCPM
megakaryocyte progenitors: 666 nCPM
platelets: 569 nCPM

Immune cell

myeloid DC: 370 nTPM
basophil: 353 nTPM
total PBMC: 330 nTPM
plasmacytoid DC: 327 nTPM
classical monocyte: 325 nTPM
memory B-cell: 297 nTPM

Brain region

thalamus: 94 nTPM
cerebellum: 94 nTPM
basal ganglia: 89 nTPM
cerebral cortex: 89 nTPM
white matter: 87 nTPM
hypothalamus: 84 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0.01
gnomAD missense Z: 1.09
DepMap mean gene effect: -0.32
DepMap dependency class: selective

OntologyGO

Biological processes

negative regulation of apoptotic process

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Sm domain, eukaryotic/archaea-type
LSM domain superfamily
Sm domain
LSM domain
LSM domain containing 1, Sm domain
Small nuclear ribonucleoprotein-associated SmB/NAA38-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAA38 as an antibody target. Whether an autoantibody or antibody against NAA38 could matter depends on whether native NAA38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAA38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAA38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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