MYOCOS
Myocilin opposite strand protein
Also known as: MYCOS_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A1B0GUC4
- Gene
- MYOCOS
- Ensembl
- ENSG00000283683
- Chromosome
- 1
- Canonical length
- 80 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for MYOCOS in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
80 residues, UniProt reviewed canonical sequence.
>A0A1B0GUC4|MYOCOS
1 MAQKSLANNS INLPYKDLTS EVTRRRVTMI TRKEIITQKS DEAKEMLSHL DLEQAPPPHR
61 TYLTVPPAPP PSPAEDPTVSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MYOCOS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 5 nTPM
Expression across tissuesHPA
Tissue
- cervix: 5 nTPM
- epididymis: 3.5 nTPM
- fallopian tube: 2.7 nTPM
- endometrium: 1.3 nTPM
- skeletal muscle: 1.3 nTPM
- testis: 1.2 nTPM
Single-cell type
- oocytes: 97 nCPM
- proximal tubule cells: 40 nCPM
- endometrial ciliated cells: 29 nCPM
- early spermatids: 27 nCPM
- endometrial glandular cells: 15 nCPM
- epididymal clear cells: 12 nCPM
Immune cell
- neutrophil: 0.3 nTPM
- T-reg: 0.2 nTPM
- basophil: 0.1 nTPM
- MAIT T-cell: 0.1 nTPM
- memory B-cell: 0.1 nTPM
- memory CD8 T-cell: 0.1 nTPM
Brain region
- cerebellum: 12 nTPM
- white matter: 10 nTPM
- cerebral cortex: 9.5 nTPM
- pons: 9.3 nTPM
- amygdala: 9.1 nTPM
- hypothalamus: 9.1 nTPM
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MYOCOS as an antibody target. Whether an autoantibody or antibody against MYOCOS could matter depends on whether native MYOCOS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MYOCOS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MYOCOS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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