MYMX
Protein myomixer
Also known as: MINION, MYMX_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A1B0GTQ4
- Gene
- MYMX
- Ensembl
- ENSG00000262179
- Chromosome
- 6
- Canonical length
- 84 aa
- Protein class
- Disease related genes, Predicted intracellular proteins
- Subcellular location
- Vesicles,Mitochondria,Cytosol
OverviewNCBI Gene
Involved in myoblast fusion involved in skeletal muscle regeneration. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Implicated in Carey-Fineman-Ziter syndrome. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
84 residues, UniProt reviewed canonical sequence.
>A0A1B0GTQ4|MYMX
1 MPTPLLPLLL RLLLSCLLLP AARLARQYLL PLLRRLARRL GSQDMREALL GCLLFILSQR
61 HSPDAGEASR VDRLERRERL GPQKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MYMX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 7.1 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 7.1 nTPM
- breast: 6.7 nTPM
- pancreas: 5.2 nTPM
- stomach: 2.2 nTPM
- blood vessel: 1.9 nTPM
- heart muscle: 1 nTPM
Single-cell type
- pdcs: 11 nCPM
- parietal cells: 5.3 nCPM
- respiratory ionocytes: 5.1 nCPM
- kupffer cells: 4.1 nCPM
- gastric chief cells: 3.3 nCPM
- extravillous trophoblasts: 2.3 nCPM
Immune cell
- plasmacytoid DC: 11 nTPM
- total PBMC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- medulla oblongata: 0.3 nTPM
- pons: 0.3 nTPM
- white matter: 0.3 nTPM
- basal ganglia: 0.2 nTPM
- cerebellum: 0.2 nTPM
- cerebral cortex: 0.2 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about MYMX.
Disease | AllUniProt
Conditions MYMX is implicated in, by any mechanism.
- Carey-Fineman-Ziter syndrome 2 (CFZS2) MIM:619941
Disease | GeneticClinVar
5 pathogenic / likely-pathogenic of 6 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Carey-Fineman-Ziter syndrome 2
OntologyGO
Biological processes
- myoblast fusion
- myoblast fusion involved in skeletal muscle regeneration
- plasma membrane fusion
- skeletal muscle organ development
- skeletal muscle tissue regeneration
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Protein myomixer
- Protein myomixer
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MYMX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MYMX as an antibody target. Whether an autoantibody or antibody against MYMX could matter depends on whether native MYMX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MYMX is annotated at the cell surface, where native MYMX is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label MYMX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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