Seroatlas · Human Serome Atlas

MYL7

Myosin regulatory light chain 2, atrial isoform

Also known as: MLRA_HUMAN, MYL2A, MYLC2A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q01449
Gene
MYL7
Ensembl
ENSG00000106631
Chromosome
7
Canonical length
175 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be involved in cardiac muscle tissue development and heart contraction. Located in A band. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

175 residues, UniProt reviewed canonical sequence.

>Q01449|MYL7
     1  MASRKAGTRG KVAATKQAQR GSSNVFSMFE QAQIQEFKEA FSCIDQNRDG IICKADLRET
    61  YSQLGKVSVP EEELDAMLQE GKGPINFTVF LTLFGEKLNG TDPEEAILSA FRMFDPSGKG
   121  VVNKDEFKQL LLTQADKFSP AEVEQMFALT PMDLAGNIDY KSLCYIITHG DEKEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYL7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
22,267 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 22,267 nTPM
  • blood vessel: 26 nTPM
  • pancreas: 17 nTPM
  • salivary gland: 11 nTPM
  • pituitary gland: 9.4 nTPM
  • hypothalamus: 6.1 nTPM

Single-cell type

  • breast myoepithelial cells: 83 nCPM
  • cardiomyocytes: 57 nCPM
  • epicardial cells: 14 nCPM
  • granulosa cells: 12 nCPM
  • somatotrophs: 6.5 nCPM
  • thyrotrophs: 3.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 3.2 nTPM
  • basal ganglia: 2 nTPM
  • midbrain: 1.8 nTPM
  • medulla oblongata: 1.5 nTPM
  • pons: 1.5 nTPM
  • cerebellum: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.62
gnomAD pLI
0
gnomAD missense Z
0.06
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYL7 as an antibody target. Whether an autoantibody or antibody against MYL7 could matter depends on whether native MYL7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYL7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYL7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MYL7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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