Seroatlas · Human Serome Atlas

MYL5

Myosin light chain 5

Also known as: MYL5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q02045
Gene: MYL5
Ensembl: ENSG00000215375
Chromosome: 4
Canonical length: 173 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes one of the myosin light chains, a component of the hexameric ATPase cellular motor protein myosin. Myosin is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene product, one of the regulatory light chains, is expressed in fetal muscle and in adult retina, cerebellum, and basal ganglia. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

173 residues, UniProt reviewed canonical sequence.

>Q02045|MYL5
     1  MASRKTKKKE GGALRAQRAS SNVFSNFEQT QIQEFKEAFT LMDQNRDGFI DKEDLKDTYA
    61  SLGKTNVKDD ELDAMLKEAS GPINFTMFLN LFGEKLSGTD AEETILNAFK MLDPDGKGKI
   121  NKEYIKRLLM SQADKMTAEE VDQMFQFASI DVAGNLDYKA LSYVITHGEE KEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

retina: 54 nTPM
cerebral cortex: 27 nTPM
amygdala: 26 nTPM
hippocampal formation: 25 nTPM
small intestine: 24 nTPM
skeletal muscle: 23 nTPM

Single-cell type

cardiomyocytes: 445 nCPM
late spermatids: 149 nCPM
thymic myoid cells: 59 nCPM
enterocytes: 52 nCPM
epididymal principal cells: 52 nCPM
esophageal suprabasal cells: 50 nCPM

Immune cell

NK-cell: 18 nTPM
basophil: 15 nTPM
plasmacytoid DC: 15 nTPM
naive B-cell: 13 nTPM
non-classical monocyte: 13 nTPM
memory B-cell: 8.7 nTPM

Brain region

cerebral cortex: 21 nTPM
white matter: 20 nTPM
medulla oblongata: 19 nTPM
pons: 18 nTPM
thalamus: 18 nTPM
cerebellum: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: -0.59
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of muscle contraction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYL5 as an antibody target. Whether an autoantibody or antibody against MYL5 could matter depends on whether native MYL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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