Seroatlas · Human Serome Atlas

MYL11

Myosin regulatory light chain 11

Also known as: HUMMLC2B, MRLC2, MYL11_HUMAN, MYLPF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A32
Gene: MYL11
Ensembl: ENSG00000180209
Chromosome: 16
Canonical length: 169 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be a structural constituent of muscle. Involved in muscle contraction. Located in lysosomal membrane. Implicated in distal arthrogryposis type 1C. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

169 residues, UniProt reviewed canonical sequence.

>Q96A32|MYL11
     1  MAPKRAKRRT VEGGSSSVFS MFDQTQIQEF KEAFTVIDQN RDGIIDKEDL RDTFAAMGRL
    61  NVKNEELDAM MKEASGPINF TVFLTMFGEK LKGADPEDVI TGAFKVLDPE GKGTIKKKFL
   121  EELLTTQCDR FSQEEIKNMW AAFPPDVGGN VDYKNICYVI THGDAKDQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYL11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 18,664 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 18,664 nTPM
tongue: 5,523 nTPM
salivary gland: 124 nTPM
esophagus: 66 nTPM
prostate: 42 nTPM
thymus: 9.3 nTPM

Single-cell type

thymic myoid cells: 3,961 nCPM
myonuclei: 239 nCPM
migrating cytotrophoblasts: 62 nCPM
late spermatids: 34 nCPM
endometrial secretory cells: 27 nCPM
fallopian secretory cells: 26 nCPM

Immune cell

plasmacytoid DC: 20 nTPM
neutrophil: 0.2 nTPM
total PBMC: 0.2 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM

Brain region

cerebellum: 1.1 nTPM
cerebral cortex: 1 nTPM
white matter: 1 nTPM
basal ganglia: 0.7 nTPM
pons: 0.6 nTPM
amygdala: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MYL11.

Disease | AllUniProt

Conditions MYL11 is implicated in, by any mechanism.

Arthrogryposis, distal, 1C (DA1C) MIM:619110

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 41 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Distal arthrogryposis
Arthrogryposis, distal, type 1C

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.76
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYL11 as an antibody target. Whether an autoantibody or antibody against MYL11 could matter depends on whether native MYL11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYL11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYL11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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