Seroatlas · Human Serome Atlas

MYL10

Myosin regulatory light chain 10

Also known as: MGC3479, MYL10_HUMAN, MYLC2PL, PLRLC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUA6
Gene: MYL10
Ensembl: ENSG00000106436
Chromosome: 7
Canonical length: 226 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

226 residues, UniProt reviewed canonical sequence.

>Q9BUA6|MYL10
     1  MLLRLVSNSW PQVILPPRPP KVLGLQAPRR ARKRAEGTAS SNVFSMFDQS QIQEFKESLA
    61  LSPRLERNGM ISAHCNLCLT GSSNSPASAS QAFTIMDQNR DGFIDKEDLR DTFAALGRIN
   121  VKNEELEAMV KEAPGPINFT VFLTMFGEKL KGTDPEETIL HAFKVFDTEG KGFVKADVIK
   181  EKLMTQADRF SEEEVKQMFA AFPPDVCGNL DYRNLCYVIT HGEEKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYL10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 1.3 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 1.3 nTPM
choroid plexus: 0.8 nTPM
pituitary gland: 0.8 nTPM
placenta: 0.7 nTPM
cervix: 0.6 nTPM
prostate: 0.6 nTPM

Single-cell type

epididymal principal cells: 11 nCPM
peritubular myoid cells: 3.2 nCPM
extravillous trophoblasts: 1.6 nCPM
thymic myoid cells: 1.4 nCPM
myosatellite cells: 1.2 nCPM
somatotrophs: 1 nCPM

Immune cell

basophil: 1.9 nTPM
neutrophil: 1 nTPM
T-reg: 0.4 nTPM
memory B-cell: 0.3 nTPM
naive B-cell: 0.3 nTPM
NK-cell: 0.3 nTPM

Brain region

cerebellum: 4.8 nTPM
cerebral cortex: 4.2 nTPM
white matter: 3.7 nTPM
choroid plexus: 3.5 nTPM
basal ganglia: 3.4 nTPM
hippocampal formation: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.01
gnomAD missense Z: -0.1
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYL10 as an antibody target. Whether an autoantibody or antibody against MYL10 could matter depends on whether native MYL10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYL10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYL10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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