Seroatlas · Human Serome Atlas

MYG1

MYG1 exonuclease

Also known as: C12orf10, Gamm1, MYG, MYG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HB07
Gene: MYG1
Ensembl: ENSG00000139637
Chromosome: 12
Canonical length: 376 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables 3'-5'-RNA exonuclease activity. Involved in mRNA processing; mitochondrial RNA metabolic process; and rRNA processing. Located in mitochondrion and nucleus. Is active in mitochondrial matrix; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>Q9HB07|MYG1
     1  MGHRFLRGLL TLLLPPPPLY TRHRMLGPES VPPPKRSRSK LMAPPRIGTH NGTFHCDEAL
    61  ACALLRLLPE YRDAEIVRTR DPEKLASCDI VVDVGGEYDP RRHRYDHHQR SFTETMSSLS
   121  PGKPWQTKLS SAGLIYLHFG HKLLAQLLGT SEEDSMVGTL YDKMYENFVE EVDAVDNGIS
   181  QWAEGEPRYA LTTTLSARVA RLNPTWNHPD QDTEAGFKRA MDLVQEEFLQ RLDFYQHSWL
   241  PARALVEEAL AQRFQVDPSG EIVELAKGAC PWKEHLYHLE SGLSPPVAIF FVIYTDQAGQ
   301  WRIQCVPKEP HSFQSRLPLP EPWRGLRDEA LDQVSGIPGC IFVHASGFIG GHRTREGALS
   361  MARATLAQRS YLPQIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

testis: 86 nTPM
choroid plexus: 47 nTPM
ovary: 41 nTPM
midbrain: 41 nTPM
hypothalamus: 39 nTPM
skeletal muscle: 38 nTPM

Single-cell type

other brain neurons: 27 nCPM
brain excitatory neurons: 16 nCPM
brain inhibitory neurons: 14 nCPM
ependymal cells: 12 nCPM
oligodendrocytes: 12 nCPM
bergmann glia: 8.7 nCPM

Immune cell

T-reg: 70 nTPM
myeloid DC: 64 nTPM
classical monocyte: 55 nTPM
MAIT T-cell: 53 nTPM
memory B-cell: 50 nTPM
total PBMC: 50 nTPM

Brain region

pons: 36 nTPM
midbrain: 34 nTPM
cerebellum: 32 nTPM
medulla oblongata: 32 nTPM
hypothalamus: 30 nTPM
thalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

3'-5'-RNA exonuclease activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

MYG1 exonuclease
Uncharacterised protein family (UPF0160)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYG1 as an antibody target. Whether an autoantibody or antibody against MYG1 could matter depends on whether native MYG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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