MYEOV
Myeloma-overexpressed gene protein
Also known as: MYEOV_HUMAN, OCIM
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96EZ4
- Gene
- MYEOV
- Ensembl
- ENSG00000172927
- Chromosome
- 11
- Canonical length
- 313 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Vesicles
OverviewNCBI Gene
No narrative summary is available for MYEOV in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
313 residues, UniProt reviewed canonical sequence.
>Q96EZ4|MYEOV
1 MALRICVTYT PALPIGLCTR CCLCLEQSPS WCHCLRGVSF LTFHLHQSVP LGDRDSLLMF
61 TRQAGHFVEG SKAGRSRGRL CLSQALRVAV RGAFVSLWFA AGAGDRERNK GDKGAQTGAG
121 LSQEAEDVDV SRARRVTDAP QGTLCGTGNR NSGSQSARVV GVAHLGEAFR VGVEQAISSC
181 PEEVHGRHGL SMEIMWARMD VALRSPGRGL LAGAGALCMT LAESSCPDYE RGRRACLTLH
241 RHPTPHCSTW GLPLRVAGSW LTVVTVEALG GWRMGVRRTG QVGPTMHPPP VSGASPLLLH
301 HLLLLLLIII LTCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MYEOV can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 11 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 11 nTPM
- stomach: 5.7 nTPM
- adipose tissue: 5.5 nTPM
- breast: 4.9 nTPM
- skin: 4.9 nTPM
- vagina: 4.3 nTPM
Single-cell type
- esophageal apical cells: 291 nCPM
- foveolar cells: 43 nCPM
- megakaryocytes: 43 nCPM
- epididymal principal cells: 35 nCPM
- platelets: 24 nCPM
- tuft cells: 23 nCPM
Immune cell
- total PBMC: 0.3 nTPM
- NK-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- medulla oblongata: 0.3 nTPM
- cerebellum: 0.2 nTPM
- cerebral cortex: 0.2 nTPM
- hypothalamus: 0.2 nTPM
- amygdala: 0.1 nTPM
- basal ganglia: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.93
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.42
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MYEOV as an antibody target. Whether an autoantibody or antibody against MYEOV could matter depends on whether native MYEOV is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MYEOV is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MYEOV as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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