Seroatlas · Human Serome Atlas

MYDGF

Myeloid-derived growth factor

Also known as: C19orf10, IL-25, IL-27, IL25, IL27, IL27w, MYDGF_HUMAN, R33729_1, SF20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969H8
Gene: MYDGF
Ensembl: ENSG00000074842
Chromosome: 19
Canonical length: 173 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

173 residues, UniProt reviewed canonical sequence.

>Q969H8|MYDGF
     1  MAAPSGGWNG VGASLWAALL LGAVALRPAE AVSEPTTVAF DVRPGGVVHS FSHNVGPGDK
    61  YTCMFTYASQ GGTNEQWQMS LGTSEDHQHF TCTIWRPQGK SYLYFTQFKA EVRGAEIEYA
   121  MAYSKAAFER ESDVPLKTEE FEVTKTAVAH RPGAFKAELS KLVIVAKASR TEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYDGF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 255 nTPM

Expression across tissuesHPA

Tissue

liver: 255 nTPM
pancreas: 212 nTPM
salivary gland: 128 nTPM
pituitary gland: 127 nTPM
spleen: 122 nTPM
epididymis: 108 nTPM

Single-cell type

extravillous trophoblasts: 1,066 nCPM
plasma cells: 793 nCPM
epididymal principal cells: 792 nCPM
syncytiotrophoblasts: 732 nCPM
decidual stromal cells: 468 nCPM
migrating cytotrophoblasts: 442 nCPM

Immune cell

plasmacytoid DC: 427 nTPM
myeloid DC: 265 nTPM
intermediate monocyte: 233 nTPM
total PBMC: 225 nTPM
classical monocyte: 217 nTPM
non-classical monocyte: 210 nTPM

Brain region

white matter: 44 nTPM
hypothalamus: 40 nTPM
choroid plexus: 39 nTPM
medulla oblongata: 35 nTPM
pons: 35 nTPM
spinal cord: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Myeloid-derived growth factor
UPF0556 domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYDGF as an antibody target. Whether an autoantibody or antibody against MYDGF could matter depends on whether native MYDGF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYDGF is annotated as secreted, so native MYDGF circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MYDGF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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