Seroatlas · Human Serome Atlas

MYCT1

Myc target protein 1

Also known as: FLJ21269, MTLC, MYCT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N699
Gene: MYCT1
Ensembl: ENSG00000120279
Chromosome: 6
Canonical length: 235 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Vesicles

OverviewNCBI Gene

Predicted to act upstream of or within hematopoietic stem cell homeostasis. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>Q8N699|MYCT1
     1  MRTQVYEGLC KNYFSLAVLQ RDRIKLLFFD ILVFLSVFLL FLLFLVDIMA NNTTSLGSPW
    61  PENFWEDLIM SFTVSMAIGL VLGGFIWAVF ICLSRRRRAS APISQWSSSR RSRSSYTHGL
   121  NRTGFYRHSG CERRSNLSLA SLTFQRQASL EQANSFPRKS SFRASTFHPF LQCPPLPVET
   181  ESQLVTLPSS NISPTISTSH SLSRPDYWSS NSLRVGLSTP PPPAYESIIK AFPDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYCT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

spleen: 47 nTPM
adipose tissue: 26 nTPM
breast: 21 nTPM
placenta: 20 nTPM
tongue: 19 nTPM
heart muscle: 17 nTPM

Single-cell type

hematopoietic stem cells: 163 nCPM
vascular endothelial cells: 149 nCPM
lymphatic endothelial cells: 141 nCPM
megakaryocyte-erythroid progenitors: 131 nCPM
platelets: 109 nCPM
megakaryocyte progenitors: 69 nCPM

Immune cell

eosinophil: 31 nTPM
basophil: 0.9 nTPM
neutrophil: 0.6 nTPM
total PBMC: 0.6 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

cerebral cortex: 15 nTPM
thalamus: 14 nTPM
pons: 11 nTPM
medulla oblongata: 8.9 nTPM
white matter: 8.3 nTPM
hypothalamus: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: 0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

hematopoietic stem cell homeostasis

Cellular components

Protein domainsUniProt · Pfam · InterPro

Myc target protein 1
Myc target protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYCT1 as an antibody target. Whether an autoantibody or antibody against MYCT1 could matter depends on whether native MYCT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYCT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYCT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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