Seroatlas · Human Serome Atlas

MYCL

Protein L-Myc

Also known as: bHLHe38, LMYC, MYCL_HUMAN, MYCL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P12524
Gene: MYCL
Ensembl: ENSG00000116990
Chromosome: 1
Canonical length: 364 aa
Protein class: Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Mitotic chromosome

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of inner ear auditory receptor cell differentiation. Located in chromosome and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>P12524|MYCL
     1  MDYDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGLGPG AGDPAPGIGP
    61  PEPWPGGCTG DEAESRGHSK GWGRNYASII RRDCMWSGFS ARERLERAVS DRLAPGAPRG
   121  NPPKASAAPD CTPSLEAGNP APAAPCPLGE PKTQACSGSE SPSDSENEEI DVVTVEKRQS
   181  LGIRKPVTIT VRADPLDPCM KHFHISIHQQ QHNYAARFPP ESCSQEEASE RGPQEEVLER
   241  DAAGEKEDEE DEEIVSPPPV ESEAAQSCHP KPVSSDTEDV TKRKNHNFLE RKRRNDLRSR
   301  FLALRDQVPT LASCSKAPKV VILSKALEYL QALVGAEKRM ATEKRQLRCR QQQLQKRIAY
   361  LTGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYCL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

pancreas: 64 nTPM
skin: 37 nTPM
esophagus: 20 nTPM
urinary bladder: 14 nTPM
vagina: 11 nTPM
liver: 11 nTPM

Single-cell type

urothelial cells: 86 nCPM
respiratory deuterosomal cells: 80 nCPM
cytotrophoblasts: 44 nCPM
prostatic hillock cells: 41 nCPM
hepatocytes: 31 nCPM
esophageal suprabasal cells: 31 nCPM

Immune cell

plasmacytoid DC: 23 nTPM
myeloid DC: 19 nTPM
classical monocyte: 17 nTPM
intermediate monocyte: 8.2 nTPM
total PBMC: 6.7 nTPM
non-classical monocyte: 3.5 nTPM

Brain region

hippocampal formation: 3.6 nTPM
hypothalamus: 3.3 nTPM
basal ganglia: 3.1 nTPM
cerebral cortex: 3.1 nTPM
spinal cord: 3 nTPM
choroid plexus: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.12
gnomAD missense Z: 1.05
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYCL as an antibody target. Whether an autoantibody or antibody against MYCL could matter depends on whether native MYCL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYCL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYCL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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