Seroatlas · Human Serome Atlas

MYADML2

Myeloid-associated differentiation marker-like protein 2

Also known as: LOC255275, MADL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NDP7
Gene: MYADML2
Ensembl: ENSG00000185105
Chromosome: 17
Canonical length: 307 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>A6NDP7|MYADML2
     1  MGSTMEPPGG AYLHLGAVTS PVGTARVLQL AFGCTTFSLV AHRGGFAGVQ GTFCMAAWGF
    61  CFAVSALVVA CEFTRLHGCL RLSWGNFTAA FAMLATLLCA TAAVLYPLYF ARRECSPEPA
   121  GCAARDFRLA ASVFAGLLFL AYAVEVALTR ARPGQVSSYM ATVSGLLKIV QAFVACIIFG
   181  ALVHDSRYGR YVATQWCVAV YSLCFLATVA VVALSVMGHT GGLGCPFDRL VVVYTFLAVL
   241  LYLSAAVIWP VFCFDPKYGE PKRPPNCARG SCPWDSQLVV AIFTYVNLLL YVVDLAYSQR
   301  IRFVPSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYADML2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 79 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 79 nTPM
tongue: 16 nTPM
cerebral cortex: 3.4 nTPM
heart muscle: 3.4 nTPM
basal ganglia: 3 nTPM
hypothalamus: 2.4 nTPM

Single-cell type

cardiomyocytes: 34 nCPM
myonuclei: 5.5 nCPM
retinal horizontal cells: 4 nCPM
brain inhibitory neurons: 1.5 nCPM
brain excitatory neurons: 0.8 nCPM
granulosa cells: 0.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 8.2 nTPM
pons: 7.3 nTPM
thalamus: 6.4 nTPM
basal ganglia: 5.9 nTPM
hypothalamus: 5.9 nTPM
amygdala: 5.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: 0.61
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYADML2 as an antibody target. Whether an autoantibody or antibody against MYADML2 could matter depends on whether native MYADML2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYADML2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYADML2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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