Seroatlas · Human Serome Atlas

MXRA8

Matrix remodeling-associated protein 8

Also known as: DKFZp586E2023, MXRA8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRK3
Gene: MXRA8
Ensembl: ENSG00000162576
Chromosome: 1
Canonical length: 442 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoli
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to be involved in establishment of glial blood-brain barrier. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

442 residues, UniProt reviewed canonical sequence.

>Q9BRK3|MXRA8
     1  MALPSRILLW KLVLLQSSAV LLHSGSSVPA AAGSSVVSES AVSWEAGARA VLRCQSPRMV
    61  WTQDRLHDRQ RVLHWDLRGP GGGPARRLLD LYSAGEQRVY EARDRGRLEL SASAFDDGNF
   121  SLLIRAVEET DAGLYTCNLH HHYCHLYESL AVRLEVTDGP PATPAYWDGE KEVLAVARGA
   181  PALLTCVNRG HVWTDRHVEE AQQVVHWDRQ PPGVPHDRAD RLLDLYASGE RRAYGPLFLR
   241  DRVAVGADAF ERGDFSLRIE PLEVADEGTY SCHLHHHYCG LHERRVFHLT VAEPHAEPPP
   301  RGSPGNGSSH SGAPGPDPTL ARGHNVINVI VPESRAHFFQ QLGYVLATLL LFILLLVTVL
   361  LAARRRRGGY EYSDQKSGKS KGKDVNLAEF AVAAGDQMLY RSEDIQLDYK NNILKERAEL
   421  AHSPLPAKYI DLDKGFRKEN CK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MXRA8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 114 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 114 nTPM
endometrium: 100 nTPM
adipose tissue: 95 nTPM
cervix: 95 nTPM
ovary: 74 nTPM
breast: 64 nTPM

Single-cell type

extravillous trophoblasts: 380 nCPM
decidual stromal cells: 285 nCPM
fibroblasts: 200 nCPM
peritubular myoid cells: 176 nCPM
leydig cells: 164 nCPM
breast myoepithelial cells: 116 nCPM

Immune cell

naive CD8 T-cell: 6.4 nTPM
naive CD4 T-cell: 0.8 nTPM
memory CD8 T-cell: 0.2 nTPM
total PBMC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

medulla oblongata: 28 nTPM
midbrain: 25 nTPM
hippocampal formation: 23 nTPM
thalamus: 22 nTPM
amygdala: 21 nTPM
cerebral cortex: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MXRA8.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 106 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Abnormal brain morphology

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: 1.05
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell adhesion
cell differentiation
establishment of glial blood-brain barrier

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MXRA8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

E1
ITGB3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MXRA8 as an antibody target. Whether an autoantibody or antibody against MXRA8 could matter depends on whether native MXRA8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MXRA8 is annotated at the cell surface, where native MXRA8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MXRA8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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