Seroatlas · Human Serome Atlas

MXRA7

Matrix-remodeling-associated protein 7

Also known as: FLJ46603, MXRA7_HUMAN, PS1TP1, TMAP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P84157
Gene: MXRA7
Ensembl: ENSG00000182534
Chromosome: 17
Canonical length: 204 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>P84157|MXRA7
     1  MEAPAELLAA LPALATALAL LLAWLLVRRG AAASPEPARA PPEPAPPAEA TGAPAPSRPC
    61  APEPAASPAG PEEPGEPAGL GELGEPAGPG EPEGPGDPAA APAEAEEQAV EARQEEEQDL
   121  DGEKGPSSEG PEEEDGEGFS FKYSPGKLRG NQYKKMMTKE ELEEEQRVQK EQLAAIFKLM
   181  KDNKETFGEM SDGDVQEQLR LYDM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MXRA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 627 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 627 nTPM
heart muscle: 494 nTPM
retina: 478 nTPM
blood vessel: 373 nTPM
seminal vesicle: 305 nTPM
colon: 297 nTPM

Single-cell type

müller glia: 181 nCPM
smooth muscle cells: 173 nCPM
rod photoreceptor cells: 126 nCPM
pancreatic islet cells: 121 nCPM
endometrial stromal cells: 117 nCPM
cone photoreceptor cells: 106 nCPM

Immune cell

NK-cell: 5.5 nTPM
memory CD8 T-cell: 4.6 nTPM
gdT-cell: 4 nTPM
total PBMC: 3.4 nTPM
MAIT T-cell: 3.1 nTPM
naive CD8 T-cell: 2.9 nTPM

Brain region

choroid plexus: 425 nTPM
basal ganglia: 231 nTPM
medulla oblongata: 140 nTPM
pons: 127 nTPM
midbrain: 124 nTPM
hippocampal formation: 123 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

megakaryocyte differentiation

Cellular components

Protein domainsUniProt · Pfam · InterPro

Matrix-remodeling-associated protein 7
Matrix-remodeling-associated protein 7, helical domain
MXRA7 helical domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MXRA7 as an antibody target. Whether an autoantibody or antibody against MXRA7 could matter depends on whether native MXRA7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MXRA7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MXRA7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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