Seroatlas · Human Serome Atlas

MUSTN1

Musculoskeletal embryonic nuclear protein 1

Also known as: MSTN1_HUMAN, Mustang

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVN3
Gene: MUSTN1
Ensembl: ENSG00000272573
Chromosome: 3
Canonical length: 82 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in glucose homeostasis and positive regulation of myoblast differentiation. Predicted to act upstream of or within positive regulation of chondrocyte differentiation; positive regulation of chondrocyte proliferation; and positive regulation of macromolecule biosynthetic process. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

82 residues, UniProt reviewed canonical sequence.

>Q8IVN3|MUSTN1
     1  MSQAGAQEAP IKKKRPPVKD EDLKGARGNL TKNQEIKSKT YQVMRECEQA GSAAPSVFSR
    61  TRTGTETVFE KPKAGPTKSV FG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MUSTN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 1,711 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 1,711 nTPM
blood vessel: 1,491 nTPM
tongue: 285 nTPM
heart muscle: 200 nTPM
adipose tissue: 132 nTPM
cervix: 114 nTPM

Single-cell type

vascular smooth muscle cells: 25 nCPM
pericytes: 14 nCPM
thymic myoid cells: 4.1 nCPM
smooth muscle cells: 2.7 nCPM
astrocytes: 1.9 nCPM
bergmann glia: 1.2 nCPM

Immune cell

neutrophil: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM
T-reg: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM

Brain region

basal ganglia: 53 nTPM
thalamus: 51 nTPM
cerebral cortex: 48 nTPM
pons: 35 nTPM
medulla oblongata: 28 nTPM
midbrain: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0
gnomAD missense Z: -0.2
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Musculoskeletal embryonic nuclear protein 1
Musculoskeletal, temporally activated-embryonic nuclear protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MUSTN1 as an antibody target. Whether an autoantibody or antibody against MUSTN1 could matter depends on whether native MUSTN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MUSTN1 is annotated as secreted, so native MUSTN1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MUSTN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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