Seroatlas · Human Serome Atlas

MUCL3

Mucin-like protein 3

Also known as: bCX105N19.6, C6orf37, DPCR1, MUCL3_HUMAN, PBLT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3MIW9
Gene: MUCL3
Ensembl: ENSG00000168631
Chromosome: 6
Canonical length: 517 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>Q3MIW9|MUCL3
     1  MAQPVHSLCS AFGLQCCLLF LLASWGAGAT TFQEYQKTGE LSTSDHIFPL TPGLVYSIPF
    61  DHIVLHSGQR PPELPKSTEI HEQKRHCNTT RHSKPTDKPT GNSKTIDHKS STDNHEAPPT
   121  SEENSSNQGK DPMIRNQRSV DPADSTTTHK ESAGKKHITP APKSKINCRK STTGKSTVTR
   181  KSDKTGRPLE KSMSTLDKTS TSSHKTTTSF HNSGNSQTKQ KSTSFPEKIT AASKTTYKTT
   241  GTPEESEKTE DSRTTVASDK LLTKTTKNIQ ETISANELTQ SLAEPTEHGG RTANENNTPS
   301  PAEPTENRER TANENKKTIC TKGKNTPVPE KPTENLGNTT LTTETIKAPV KSTENPEKTA
   361  AVTKTIKPSV KVTGDKSLTT TSSHLNKTEV THQVPTGSFT LITSRTKLSS ITSEATGNES
   421  HPYLNKDGSQ KGIHAGQMGE NDSFPAWAIV IVVLVAVILL LVFLGLIFLV SYMMRTRRTL
   481  TQNTQYNDAE DEGGPNSYPV YLMEQQNLGM GQIPSPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MUCL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 192 nTPM

Expression across tissuesHPA

Tissue

stomach: 192 nTPM
esophagus: 10 nTPM
gallbladder: 9.3 nTPM
lung: 3.4 nTPM
vagina: 1.9 nTPM
cervix: 0.9 nTPM

Single-cell type

foveolar cells: 29 nCPM
mucous neck cells: 2.4 nCPM
cholangiocytes: 1.3 nCPM
gastric chief cells: 1.1 nCPM
esophageal apical cells: 0.8 nCPM
renal collecting duct principal cells: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Mucin-like protein 3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MUCL3 as an antibody target. Whether an autoantibody or antibody against MUCL3 could matter depends on whether native MUCL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MUCL3 is annotated at the cell surface, where native MUCL3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MUCL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...