Seroatlas · Human Serome Atlas

MUCL1

Mucin-like protein 1

Also known as: MUCL1_HUMAN, SBEM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96DR8
Gene
MUCL1
Ensembl
ENSG00000172551
Chromosome
12
Canonical length
90 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Predicted to be located in Golgi lumen and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

90 residues, UniProt reviewed canonical sequence.

>Q96DR8|MUCL1
     1  MKFLAVLVLL GVSIFLVSAQ NPTTAAPADT YPATGPADDE APDAETTAAA TTATTAAPTT
    61  ATTAASTTAR KDIPVLPKWV GDLPNGRVCP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MUCL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
3,039 nTPM

Expression across tissuesHPA

Tissue

  • breast: 3,039 nTPM
  • skin: 777 nTPM
  • salivary gland: 195 nTPM
  • adipose tissue: 35 nTPM
  • thymus: 2.3 nTPM
  • kidney: 2.1 nTPM

Single-cell type

  • breast hormone-responsive cells: 7,511 nCPM
  • salivary acinar cells: 634 nCPM
  • salivary myoepithelial cells: 76 nCPM
  • breast secretory cells: 50 nCPM
  • epididymal clear cells: 31 nCPM
  • breast myoepithelial cells: 29 nCPM

Immune cell

  • memory CD4 T-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • cerebral cortex: 0.8 nTPM
  • white matter: 0.7 nTPM
  • basal ganglia: 0.5 nTPM
  • medulla oblongata: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.91
gnomAD pLI
0
gnomAD missense Z
-0.65
DepMap mean gene effect
-0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Mucin-like protein 1
  • Mucin-like protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MUCL1 as an antibody target. Whether an autoantibody or antibody against MUCL1 could matter depends on whether native MUCL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MUCL1 is annotated as secreted, so native MUCL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MUCL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MUCL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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