Seroatlas · Human Serome Atlas

MUC22

Mucin-22

Also known as: MUC22_HUMAN, PBMUCL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
E2RYF6
Gene
MUC22
Ensembl
ENSG00000261272
Chromosome
6
Canonical length
1773 aa
Protein class
Human disease related genes, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1773 residues, UniProt reviewed canonical sequence.

>E2RYF6|MUC22
     1  MRRGNISPAF WFLWLLLFGL LGPSSENTTA FTKGSDTTTA SITGSETTMA STMASTSALT
    61  TGSKITTDST TGSETTSAST MASTAAFTTG SETNTASTTD SGTTIASTRT FTTGSDTTTG
   121  STAGSETIVA STTVSGTTTT FTIASTTVPE TTMASSTTST AGSEKTMASS IISETTMAST
   181  TGSETATVST TGSETTTTST ASSEATKVST TGSETTTAST AGSETTTTST SMAGSEATTT
   241  STADSKVITA SSMSSETTVA PAAGSNTTTA STTGSETTTI LIKASETTTA STAGSETTTP
   301  SPTGSQTTIV SISGSEITTT STAGSENTTV SSAGSGTTTA SMAGSETTVS TAGSETTTVS
   361  ITGTETTMVS AMGSETTTNS TTSSETTVTS TAGSETTTVS TVGSETTTAY TADSETTAAS
   421  TTGSEMTTVF TAGSETITPS TAGSETTTVS TAGSETTTVS TTGSETTTAS TAHSETTAAS
   481  TMGSETTKVS TAGSETTVST AGSETTAAST EDSETNTAFT EDSKTTTAST TGFETTAAST
   541  TGSEPTMAST MGSETTMAST IGPETTKVST ASSEVTTVFA AGSETIRAST VGSETTTVST
   601  TGSETTTASI MGSETSTDST TGSETTTAST EGSETTTAST EGSEATTVST TGSETTTVSI
   661  TDSETTTTCT EGSEMTAVST TVFETTTAST EGSEITIAST SDSETTTAST EGSETTTVTT
   721  AGSETKTAYT TGSETTTASN TGLETTTVFT IGSDTTTAST EGSETTAVSA TGSEMTTVST
   781  EGSENTTVST TGSETTTVST TGLETTTTST EGSEMTTVST TGAETTTDST EGSGTTAAST
   841  AGSETTTVST ADSENTTAST ADSETTSAST TGSETTTAST TSSETTTAST EGSETTTVST
   901  TDSETTMVST TGSERTITST EGSETTTVSA TGSETTVSTE GSGTTTVSIT GSETTKVSTT
   961  GSETTTTSTE GSEITTASIT GSETTTASTE GSETTTASTE GSETTSASTT GSETTTASTT
  1021  SSETTMASIM GSETTMASTI GSETTKVSTA SSKMTTVFTE NSETTIASTT ASETTTVSTA
  1081  GSETIPASTA GSETTTTTST EGSETTTAST EGSETTTAST ESSETTTATT IGSETTTAST
  1141  EGSETTTTST EGSETTTAST EGSEITTVST TGSETTTAST EGSETTTAST EGSELTTVST
  1201  TGSETITVSA EGSETTTVTT MGSETTTAST AGSETTTVST AGSETTTASI EGSETTTVSS
  1261  TGSETTTVST TGTETTITST EGSETTTVTT AGSETTAVYT TGSETTTTST EGSETTTVST
  1321  TGSETTTAST ADLETTTVST SGSGTTTAST AGSETTTVYI TGSKTTTAST EGSEATTVST
  1381  TSSETTTAST TGSEMTTVFT TVSETTTVST IGSEATTSSA AGSEATTTST EGSETTTAST
  1441  AGSETTTAST AGSETTTAST SGSETNTACT TGSETSTPSS AGSETNTAFI IGSESTIAST
  1501  ASLEPTATSL TGSETTTVSI TASGATAAST TVSSTTFVLT KATDVSIQPI TNTPMSGTRT
  1561  TGTRLTASSS VTMAPGMDFT ASAASHTVPG IVLNTSGLGT STMGASSTTS AHGVRTTTGS
  1621  TREPTSSTFQ ETGPVSMGTN TVSMSHTPTN VIKPSGYLQP WAIILISLAA VVAAVGLSVG
  1681  LSFCLRNLFF PLRYCGIYYP HGHSHSLGLD LNLGLGSGTF HSLGNALVHG GELEMGHGGT
  1741  HGFGYGVGHG LSHIHGDGYG VNHGGHYGHG GGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MUC22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 17 nTPM
  • cervix: 2.5 nTPM
  • vagina: 2.2 nTPM
  • tonsil: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • microglia: 5.3 nCPM
  • ocular epithelial cells: 3 nCPM
  • proximal tubule cells: 0.6 nCPM
  • esophageal apical cells: 0.5 nCPM
  • early primary spermatocytes: 0.2 nCPM
  • ependymal cells: 0.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 0.1 nTPM
  • spinal cord: 0.1 nTPM
  • thalamus: 0.1 nTPM
  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0.01
gnomAD missense Z
2.65
DepMap mean gene effect
0.14
DepMap dependency class
none

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MUC22 as an antibody target. Whether an autoantibody or antibody against MUC22 could matter depends on whether native MUC22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MUC22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MUC22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MUC22. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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