MUC21

Protein identityUniProt · HPA

UniProt accession

Q5SSG8

Gene

MUC21

Ensembl

ENSG00000204544

Chromosome

6

Canonical length

566 aa

Protein class

Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a large membrane-bound glycoprotein which is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. The encoded protein contains an N-terminal signal sequence, an extracellular mucin domain, a stem domain, a transmembrane domain, and a C-terminal cytoplasmic tail domain. The mucin domain contains O-glycosylation sites and is polymorphic with isoforms containing a variable number of nonidentical proline-, threonine-, and serine-rich tandem repeats of 15 amino acids each. The aberrent expression of this gene is associated with lung adenocarcinoma. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

566 residues, UniProt reviewed canonical sequence.

>Q5SSG8|MUC21
     1  MKMQKGNVLL MFGLLLHLEA ATNSNETSTS ANTGSSVISS GASTATNSGS SVTSSGVSTA
    61  TISGSSVTSN GVSIVTNSEF HTTSSGISTA TNSEFSTVSS GISIATNSES STTSSGASTA
   121  TNSESSTPSS GASTATNSDS STTSSGASTA TNSDSSTTSS EASTATNSES STTSSGASTA
   181  TNSESSTVSS RASTATNSES STTSSGASTA TNSESRTTSN GAGTATNSES STTSSGASTA
   241  TNSESSTPSS GAGTATNSES STTSSGAGTA TNSESSTVSS GISTVTNSES STPSSGANTA
   301  TNSESSTTSS GANTATNSDS STTSSGASTA TNSESSTTSS GASTATNSES STTSSGASTA
   361  TNSGSSTTSS GTSTATNSES STVSSGASTA TTSESSTTSS GASTATNSES STVSSGASTA
   421  TNSESSTTSS GANTATNSGS SVTSAGSGTA ALTGMHTTSH SASTAVSEAK PGGSLVPWEI
   481  FLITLVSVVA AVGLFAGLFF CVRNSLSLRN TFNTAVYHPH GLNHGLGPGP GGNHGAPHRP
   541  RWSPNWFWRR PVSSIAMEMS GRNSGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MUC21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

662 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.41

gnomAD pLI

0.08

gnomAD missense Z

0.57

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of cell-cell adhesion

Cellular components

• Golgi lumen
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Mucin, catalytic, TM and cytoplasmic tail domain
• Mucin, cleavage site, TM and cytoplasmic tail region
• Tandem-repeating region of mucin, epiglycanin-like
• Tandem-repeating region of mucin, epiglycanin-like

KeywordsUniProt

• Cell membrane
• Glycoprotein
• Membrane
• Repeat
• Signal
• Transmembrane
• Transmembrane helix