MUC20

Protein identityUniProt · HPA

UniProt accession

Q8N307

Gene

MUC20

Ensembl

ENSG00000176945

Chromosome

3

Canonical length

709 aa

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

Secretome location

Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

709 residues, UniProt reviewed canonical sequence.

>Q8N307|MUC20
     1  MGCLWGLALP LFFFCWEVGV SGSSAGPSTR RADTAMTTDD TEVPAMTLAP GHAALETQTL
    61  SAETSSRAST PAGPIPEAET RGAKRISPAR ETRSFTKTSP NFMVLIATSV ETSAASGSPE
   121  GAGMTTVQTI TGSDPREAIF DTLCTDDSSE EAKTLTMDIL TLAHTSTEAK GLSSESSASS
   181  DSPHPVITPS RASESSASSD GPHPVITPSR ASESSASSDG PHPVITPSRA SESSASSDGP
   241  HPVITPSRAS ESSASSDGPH PVITPSRASE SSASSDGPHP VITPSRASES SASSDGPHPV
   301  ITPSRASESS ASSDGPHPVI TPSRASESSA SSDGPHPVIT PSRASESSAS SDGLHPVITP
   361  SRASESSASS DGPHPVITPS RASESSASSD GPHPVITPSW SPGSDVTLLA EALVTVTNIE
   421  VINCSITEIE TTTSSIPGAS DTDLIPTEGV KASSTSDPPA LPDSTEAKPH ITEVTASAET
   481  LSTAGTTESA APDATVGTPL PTNSATEREV TAPGATTLSG ALVTVSRNPL EETSALSVET
   541  PSYVKVSGAA PVSIEAGSAV GKTTSFAGSS ASSYSPSEAA LKNFTPSETP TMDIATKGPF
   601  PTSRDPLPSV PPTTTNSSRG TNSTLAKITT SAKTTMKPPT ATPTTARTRP TTDVSAGENG
   661  GFLLLRLSVA SPEDLTDPRV AERLMQQLHR ELHAHAPHFQ VSLLRVRRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MUC20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.53

Highest tissue expression

51 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.1

gnomAD pLI

0

gnomAD missense Z

0.08

DepMap mean gene effect

-0.23

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• hepatocyte growth factor receptor signaling pathway

Molecular functions

• identical protein binding

Cellular components

• apical plasma membrane
• basal plasma membrane
• basolateral plasma membrane
• extracellular region
• Golgi lumen
• microvillus membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Mucin-20
• Mucin-20 repeat
• Mucin-20 protein

KeywordsUniProt

• Cell membrane
• Cell projection
• Glycoprotein
• Membrane
• Repeat
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of MUC20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MET