Seroatlas · Human Serome Atlas

MUC17

Mucin-17

Also known as: MUC17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q685J3
Gene
MUC17
Ensembl
ENSG00000169876
Chromosome
7
Canonical length
4493 aa
Protein class
Cancer-related genes, Predicted membrane proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

4493 residues, UniProt reviewed canonical sequence.

>Q685J3|MUC17
     1  MPRPGTMALC LLTLVLSLLP PQAAAEQDLS VNRAVWDGGG CISQGDVLNR QCQQLSQHVR
    61  TGSAANTATG TTSTNVVEPR MYLSCSTNPE MTSIESSVTS DTPGVSSTRM TPTESRTTSE
   121  STSDSTTLFP SSTEDTSSPT TPEGTDVPMS TPSEESISST MAFVSTAPLP SFEAYTSLTY
   181  KVDMSTPLTT STQASSSPTT PESTTIPKST NSEGSTPLTS MPASTMKVAS SEAITLLTTP
   241  VEISTPVTIS AQASSSPTTA EGPSLSNSAP SGGSTPLTRM PLSVMLVVSS EASTLSTTPA
   301  ATNIPVITST EASSSPTTAE GTSIPTSTYT EGSTPLTSTP ASTMPVATSE MSTLSITPVD
   361  TSTLVTTSTE PSSLPTTAEA TSMLTSTLSE GSTPLTNMPV STILVASSEA STTSTIPVDS
   421  KTFVTTASEA SSSPTTAEDT SIATSTPSEG STPLTSMPVS TTPVASSEAS NLSTTPVDSK
   481  TQVTTSTEAS SSPPTAEVNS MPTSTPSEGS TPLTSMSVST MPVASSEAST LSTTPVDTST
   541  PVTTSSEASS SSTTPEGTSI PTSTPSEGST PLTNMPVSTR LVVSSEASTT STTPADSNTF
   601  VTTSSEASSS STTAEGTSMP TSTYSERGTT ITSMSVSTTL VASSEASTLS TTPVDSNTPV
   661  TTSTEATSSS TTAEGTSMPT STYTEGSTPL TSMPVNTTLV ASSEASTLST TPVDTSTPVT
   721  TSTEASSSPT TADGASMPTS TPSEGSTPLT SMPVSKTLLT SSEASTLSTT PLDTSTHITT
   781  STEASCSPTT TEGTSMPIST PSEGSPLLTS IPVSITPVTS PEASTLSTTP VDSNSPVTTS
   841  TEVSSSPTPA EGTSMPTSTY SEGRTPLTSM PVSTTLVATS AISTLSTTPV DTSTPVTNST
   901  EARSSPTTSE GTSMPTSTPG EGSTPLTSMP DSTTPVVSSE ARTLSATPVD TSTPVTTSTE
   961  ATSSPTTAEG TSIPTSTPSE GTTPLTSTPV SHTLVANSEA STLSTTPVDS NTPLTTSTEA
  1021  SSPPPTAEGT SMPTSTPSEG STPLTRMPVS TTMVASSETS TLSTTPADTS TPVTTYSQAS
  1081  SSSTTADGTS MPTSTYSEGS TPLTSVPVST RLVVSSEAST LSTTPVDTSI PVTTSTEASS
  1141  SPTTAEGTSI PTSPPSEGTT PLASMPVSTT LVVSSEANTL STTPVDSKTQ VATSTEASSP
  1201  PPTAEVTSMP TSTPGERSTP LTSMPVRHTP VASSEASTLS TSPVDTSTPV TTSAETSSSP
  1261  TTAEGTSLPT STTSEGSTLL TSIPVSTTLV TSPEASTLLT TPVDTKGPVV TSNEVSSSPT
  1321  PAEGTSMPTS TYSEGRTPLT SIPVNTTLVA SSAISILSTT PVDNSTPVTT STEACSSPTT
  1381  SEGTSMPNSN PSEGTTPLTS IPVSTTPVVS SEASTLSATP VDTSTPGTTS AEATSSPTTA
  1441  EGISIPTSTP SEGKTPLKSI PVSNTPVANS EASTLSTTPV DSNSPVVTST AVSSSPTPAE
  1501  GTSIAISTPS EGSTALTSIP VSTTTVASSE INSLSTTPAV TSTPVTTYSQ ASSSPTTADG
  1561  TSMQTSTYSE GSTPLTSLPV STMLVVSSEA NTLSTTPIDS KTQVTASTEA SSSTTAEGSS
  1621  MTISTPSEGS PLLTSIPVST TPVASPEAST LSTTPVDSNS PVITSTEVSS SPTPAEGTSM
  1681  PTSTYTEGRT PLTSITVRTT PVASSAISTL STTPVDNSTP VTTSTEARSS PTTSEGTSMP
  1741  NSTPSEGTTP LTSIPVSTTP VLSSEASTLS ATPIDTSTPV TTSTEATSSP TTAEGTSIPT
  1801  STLSEGMTPL TSTPVSHTLV ANSEASTLST TPVDSNSPVV TSTAVSSSPT PAEGTSIATS
  1861  TPSEGSTALT SIPVSTTTVA SSETNTLSTT PAVTSTPVTT YAQVSSSPTT ADGSSMPTST
  1921  PREGRPPLTS IPVSTTTVAS SEINTLSTTL ADTRTPVTTY SQASSSPTTA DGTSMPTPAY
  1981  SEGSTPLTSM PLSTTLVVSS EASTLSTTPV DTSTPATTST EGSSSPTTAG GTSIQTSTPS
  2041  ERTTPLAGMP VSTTLVVSSE GNTLSTTPVD SKTQVTNSTE ASSSATAEGS SMTISAPSEG
  2101  SPLLTSIPLS TTPVASPEAS TLSTTPVDSN SPVITSTEVS SSPIPTEGTS MQTSTYSDRR
  2161  TPLTSMPVST TVVASSAIST LSTTPVDTST PVTNSTEARS SPTTSEGTSM PTSTPSEGST
  2221  PFTSMPVSTM PVVTSEASTL SATPVDTSTP VTTSTEATSS PTTAEGTSIP TSTLSEGTTP
  2281  LTSIPVSHTL VANSEVSTLS TTPVDSNTPF TTSTEASSPP PTAEGTSMPT STSSEGNTPL
  2341  TRMPVSTTMV ASFETSTLST TPADTSTPVT TYSQAGSSPT TADDTSMPTS TYSEGSTPLT
  2401  SVPVSTMPVV SSEASTHSTT PVDTSTPVTT STEASSSPTT AEGTSIPTSP PSEGTTPLAS
  2461  MPVSTTPVVS SEAGTLSTTP VDTSTPMTTS TEASSSPTTA EDIVVPISTA SEGSTLLTSI
  2521  PVSTTPVASP EASTLSTTPV DSNSPVVTST EISSSATSAE GTSMPTSTYS EGSTPLRSMP
  2581  VSTKPLASSE ASTLSTTPVD TSIPVTTSTE TSSSPTTAKD TSMPISTPSE VSTSLTSILV
  2641  STMPVASSEA STLSTTPVDT RTLVTTSTGT SSSPTTAEGS SMPTSTPGER STPLTNILVS
  2701  TTLLANSEAS TLSTTPVDTS TPVTTSAEAS SSPTTAEGTS MRISTPSDGS TPLTSILVST
  2761  LPVASSEAST VSTTAVDTSI PVTTSTEASS SPTTAEVTSM PTSTPSETST PLTSMPVNHT
  2821  PVASSEAGTL STTPVDTSTP VTTSTKASSS PTTAEGIVVP ISTASEGSTL LTSIPVSTTP
  2881  VASSEASTLS TTPVDTSIPV TTSTEGSSSP TTAEGTSMPI STPSEVSTPL TSILVSTVPV
  2941  AGSEASTLST TPVDTRTPVT TSAEASSSPT TAEGTSMPIS TPGERRTPLT SMSVSTMPVA
  3001  SSEASTLSRT PADTSTPVTT STEASSSPTT AEGTGIPIST PSEGSTPLTS IPVSTTPVAI
  3061  PEASTLSTTP VDSNSPVVTS TEVSSSPTPA EGTSMPISTY SEGSTPLTGV PVSTTPVTSS
  3121  AISTLSTTPV DTSTPVTTST EAHSSPTTSE GTSMPTSTPS EGSTPLTYMP VSTMLVVSSE
  3181  DSTLSATPVD TSTPVTTSTE ATSSTTAEGT SIPTSTPSEG MTPLTSVPVS NTPVASSEAS
  3241  ILSTTPVDSN TPLTTSTEAS SSPPTAEGTS MPTSTPSEGS TPLTSMPVST TTVASSETST
  3301  LSTTPADTST PVTTYSQASS SPPIADGTSM PTSTYSEGST PLTNMSFSTT PVVSSEASTL
  3361  STTPVDTSTP VTTSTEASLS PTTAEGTSIP TSSPSEGTTP LASMPVSTTP VVSSEVNTLS
  3421  TTPVDSNTLV TTSTEASSSP TIAEGTSLPT STTSEGSTPL SIMPLSTTPV ASSEASTLST
  3481  TPVDTSTPVT TSSPTNSSPT TAEVTSMPTS TAGEGSTPLT NMPVSTTPVA SSEASTLSTT
  3541  PVDSNTFVTS SSQASSSPAT LQVTTMRMST PSEGSSSLTT MLLSSTYVTS SEASTPSTPS
  3601  VDRSTPVTTS TQSNSTPTPP EVITLPMSTP SEVSTPLTIM PVSTTSVTIS EAGTASTLPV
  3661  DTSTPVITST QVSSSPVTPE GTTMPIWTPS EGSTPLTTMP VSTTRVTSSE GSTLSTPSVV
  3721  TSTPVTTSTE AISSSATLDS TTMSVSMPME ISTLGTTILV STTPVTRFPE SSTPSIPSVY
  3781  TSMSMTTASE GSSSPTTLEG TTTMPMSTTS ERSTLLTTVL ISPISVMSPS EASTLSTPPG
  3841  DTSTPLLTST KAGSFSIPAE VTTIRISITS ERSTPLTTLL VSTTLPTSFP GASIASTPPL
  3901  DTSTTFTPST DTASTPTIPV ATTISVSVIT EGSTPGTTIF IPSTPVTSST ADVFPATTGA
  3961  VSTPVITSTE LNTPSTSSSS TTTSFSTTKE FTTPAMTTAA PLTYVTMSTA PSTPRTTSRG
  4021  CTTSASTLSA TSTPHTSTSV TTRPVTPSSE SSRPSTITSH TIPPTFPPAH SSTPPTTSAS
  4081  STTVNPEAVT TMTTRTKPST RTTSFPTVTT TAVPTNTTIK SNPTSTPTVP RTTTCFGDGC
  4141  QNTASRCKNG GTWDGLKCQC PNLYYGELCE EVVSSIDIGP PETISAQMEL TVTVTSVKFT
  4201  EELKNHSSQE FQEFKQTFTE QMNIVYSGIP EYVGVNITKL RLGSVVVEHD VLLRTKYTPE
  4261  YKTVLDNATE VVKEKITKVT TQQIMINDIC SDMMCFNTTG TQVQNITVTQ YDPEEDCRKM
  4321  AKEYGDYFVV EYRDQKPYCI SPCEPGFSVS KNCNLGKCQM SLSGPQCLCV TTETHWYSGE
  4381  TCNQGTQKSL VYGLVGAGVV LMLIILVALL MLVFRSKREV KRQKYRLSQL YKWQEEDSGP
  4441  APGTFQNIGF DICQDDDSIH LESIYSNFQP SLRHIDPETK IRIQRPQVMT TSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MUC17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 41 nTPM
  • duodenum: 21 nTPM
  • rectum: 3.2 nTPM
  • colon: 2.4 nTPM
  • stomach: 0.6 nTPM
  • smooth muscle: 0.3 nTPM

Single-cell type

  • enterocytes: 1,256 nCPM
  • gastric progenitor cells: 127 nCPM
  • enteric transient amplifying cells: 124 nCPM
  • foveolar cells: 108 nCPM
  • colonocytes: 104 nCPM
  • goblet cells: 95 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • cerebellum: 0 nTPM
  • choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0
gnomAD missense Z
-7.83
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MUC17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MUC17 as an antibody target. Whether an autoantibody or antibody against MUC17 could matter depends on whether native MUC17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MUC17 is annotated at the cell surface, where native MUC17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MUC17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MUC17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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