MUC15
Mucin-15
Also known as: MUC15_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N387
- Gene
- MUC15
- Ensembl
- ENSG00000169550
- Chromosome
- 11
- Canonical length
- 334 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Predicted to be located in Golgi lumen and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
334 residues, UniProt reviewed canonical sequence.
>Q8N387|MUC15
1 MLALAKILLI STLFYSLLSG SHGKENQDIN TTQNIAEVFK TMENKPISLE SEANLNSDKE
61 NITTSNLKAS HSPPLNLPNN SHGITDFSSN SSAEHSLGSL KPTSTISTSP PLIHSFVSKV
121 PWNAPIADED LLPISAHPNA TPALSSENFT WSLVNDTVKT PDNSSITVSI LSSEPTSPSV
181 TPLIVEPSGW LTTNSDSFTG FTPYQEKTTL QPTLKFTNNS KLFPNTSDPQ KENRNTGIVF
241 GAILGAILGV SLLTLVGYLL CGKRKTDSFS HRRLYDDRNE PVLRLDNAPE PYDVSFGNSS
301 YYNPTLNDSA MPESEENARD GIPMDDIPPL RTSVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MUC15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 1,841 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 1,841 nTPM
- thyroid gland: 71 nTPM
- salivary gland: 49 nTPM
- skin: 28 nTPM
- kidney: 23 nTPM
- esophagus: 15 nTPM
Single-cell type
- epididymal principal cells: 5,405 nCPM
- syncytiotrophoblasts: 1,091 nCPM
- breast lactating cells: 308 nCPM
- esophageal apical cells: 226 nCPM
- respiratory ciliated cells: 174 nCPM
- salivary duct cells: 165 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- basal ganglia: 11 nTPM
- choroid plexus: 4.1 nTPM
- cerebral cortex: 2.7 nTPM
- hippocampal formation: 2.5 nTPM
- amygdala: 2.4 nTPM
- white matter: 2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.27
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.56
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Cell-membrane associated Mucin-15
- Cell-membrane associated Mucin15
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MUC15 as an antibody target. Whether an autoantibody or antibody against MUC15 could matter depends on whether native MUC15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MUC15 is annotated at the cell surface, where native MUC15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label MUC15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...